Associations of polymorphisms in the candidate genes for Alzheimer’s disease BIN1, CLU, CR1 and PICALM with gestational diabetes and impaired glucose tolerance
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology Reports"
DOI: 10.1007/s11033-017-4100-9
Abstract: Alzheimer’s disease (AD) is the most common type of dementia, with a prevalence that is rising every year. AD is associated with type 2 diabetes mellitus (T2DM) and insulin resistance, and is therefore sometimes called… read more here.
Keywords: alzheimer disease; cr1; clu; candidate genes ... See more keywords
Associations between CLU polymorphisms and memory performance: The role of serum lipids in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2020.07.015
Abstract: CLU encoding clusterin, has been reported to associate with Alzherimer's disease (AD) by genome-wide association studies (GWAS) based on Caucasian populations. Our previous case-control study has independently confirmed the disease association of CLU in Chinese… read more here.
Keywords: clu; disease; serum; memory performance ... See more keywords
Glycosylation of Serum Clusterin in Wild-Type Transthyretin-Associated (ATTRwt) Amyloidosis: A Study of Disease-Associated Compositional Features Using Mass Spectrometry Analyses.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00590
Abstract: Wild-type transthyretin-associated (ATTRwt) amyloidosis is an age-related disease that causes heart failure in older adults. This disease frequently features cardiac amyloid fibril deposits that originate from dissociation of the tetrameric protein, transthyretin (TTR). Unlike hereditary… read more here.
Keywords: clu; amyloidosis; attrwt amyloidosis; wild type ... See more keywords
Dysregulation of HNF1B/Clusterin Axis Enhances Disease Progression in a Highly Aggressive Subset of Pancreatic Cancer Patients.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac092
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and is largely refractory to available treatments. Identifying key pathways associated with disease aggressiveness and therapeutic resistance may characterize candidate targets to improve patient outcome. We used… read more here.
Keywords: pancreatic cancer; clu; patient; disease progression ... See more keywords
Inhibition of Clusterin Represses Proliferation by Inducing Cellular Senescence in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-022-11668-0
Abstract: The outcome of pancreatic ductal adenocarcinoma (PDAC) is unsatisfactory, and the identification of novel therapeutic targets is urgently needed. Clinical studies on the antisense oligonucleotide that targets clusterin (CLU) expression have been conducted and have… read more here.
Keywords: clu; senescence; inducing cellular; cellular senescence ... See more keywords
Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2018.00504
Abstract: Our understanding of the molecular processes underlying Alzheimer’s disease (AD) is still limited, hindering the development of effective treatments, and highlighting the need for human-specific models. Advances in identifying components of the amyloid cascade are… read more here.
Keywords: derived neurons; clu; amyloid toxicity; ipsc derived ... See more keywords
Impacts of AD-Related ABCA7 and CLU Variants on Default Mode Network Connectivity in Healthy Middle-Age Adults
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.00145
Abstract: Objective To investigate the impact of Alzheimer’s disease (AD)-related risk gene (ATP-binding cassette A7-ABCA7 and Clusterin-CLU) on the functional connectivity pattern of default mode network (DMN) in healthy middle-age adults. Methods A total of 147… read more here.
Keywords: risk group; risk; clu; functional connectivity ... See more keywords
Clusterin and Its Isoforms in Oral Squamous Cell Carcinoma and Their Potential as Biomarkers: A Comprehensive Review
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051458
Abstract: Oral squamous cell carcinoma (OSCC) is a prevalent type of head and neck cancer, ranked as the sixth most common cancer worldwide, accounting for approximately 300,000 new cases and 145,000 deaths annually. Early detection using… read more here.
Keywords: comprehensive review; cell carcinoma; cell; clu ... See more keywords
Neuronal Hyperactivation in EEG Data during Cognitive Tasks Is Related to the Apolipoprotein J/Clusterin Genotype in Nondemented Adults
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076790
Abstract: The clusterin (CLU) rs11136000 CC genotype is a probable risk factor for Alzheimer’s disease (AD). CLU, also known as the apolipoprotein J gene, shares certain properties with the apolipoprotein E (APOE) gene with a well-established… read more here.
Keywords: neuronal hyperactivation; clu; task; cognitive tasks ... See more keywords
The research progress of clusterin in prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "International Urology and Nephrology"
DOI: 10.3760/cma.j.issn.1673-4416.2020.01.055
Abstract: 丛生蛋白(CLU)是一种凋亡相关蛋白，广泛存在于人体体液和组织中，参与多种病理生理过程。研究表明CLU表达异常与某些恶性肿瘤发生发展密切相关。在前列腺癌(PCa)恶化、转移、治疗过程中，PCa从激素依赖型转变为非激素依赖型的过程中常伴随着CLU的高表达。靶向CLU基因的治疗能增加前列腺肿瘤对放化疗、雄激素撤退治疗的敏感度。本文就CLU在前列腺癌发生发展中的作用作一综述。 read more here.
Keywords: clu; clusterin prostate; clu clu; prostate cancer ... See more keywords