Associations of polymorphisms in the candidate genes for Alzheimer’s disease BIN1, CLU, CR1 and PICALM with gestational diabetes and impaired glucose tolerance
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology Reports"
DOI: 10.1007/s11033-017-4100-9
Abstract: Alzheimer’s disease (AD) is the most common type of dementia, with a prevalence that is rising every year. AD is associated with type 2 diabetes mellitus (T2DM) and insulin resistance, and is therefore sometimes called… read more here.
Keywords: alzheimer disease; cr1; clu; candidate genes ... See more keywords
Associations between CLU polymorphisms and memory performance: The role of serum lipids in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2020.07.015
Abstract: CLU encoding clusterin, has been reported to associate with Alzherimer's disease (AD) by genome-wide association studies (GWAS) based on Caucasian populations. Our previous case-control study has independently confirmed the disease association of CLU in Chinese… read more here.
Keywords: clu; disease; serum; memory performance ... See more keywords
Glycosylation of Serum Clusterin in Wild-Type Transthyretin-Associated (ATTRwt) Amyloidosis: A Study of Disease-Associated Compositional Features Using Mass Spectrometry Analyses.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00590
Abstract: Wild-type transthyretin-associated (ATTRwt) amyloidosis is an age-related disease that causes heart failure in older adults. This disease frequently features cardiac amyloid fibril deposits that originate from dissociation of the tetrameric protein, transthyretin (TTR). Unlike hereditary… read more here.
Keywords: clu; amyloidosis; attrwt amyloidosis; wild type ... See more keywords
Astrocyte-derived clusterin disrupts glial physiology to obstruct remyelination in mouse models of demyelinating diseases
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52142-7
Abstract: Multiple sclerosis (MS) is a debilitating demyelinating disease characterized by remyelination failure attributed to inadequate oligodendrocyte precursor cells (OPCs) differentiation and aberrant astrogliosis. A comprehensive cell atlas reanalysis of clinical specimens brings to light heightened… read more here.
Keywords: physiology; mouse models; clu; remyelination ... See more keywords
Clusterin mediates hydroquinone-induced cytotoxic responses in HL-60 differentiated cells
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-82140-0
Abstract: Benzene is a crucial industrial hydrocarbon, posing significant health risks due to its toxic metabolites like hydroquinone (HQ). This study investigates the role of clusterin (CLU) in benzene toxicity by analyzing its protein and mRNA… read more here.
Keywords: like cells; neutrophil like; mrna levels; clu ... See more keywords
Dysregulation of HNF1B/Clusterin Axis Enhances Disease Progression in a Highly Aggressive Subset of Pancreatic Cancer Patients.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac092
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and is largely refractory to available treatments. Identifying key pathways associated with disease aggressiveness and therapeutic resistance may characterize candidate targets to improve patient outcome. We used… read more here.
Keywords: pancreatic cancer; clu; patient; disease progression ... See more keywords
Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the lifespan.
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood.2024025776
Abstract: Hematopoietic stem cells (HSCs) exhibit significant age-related phenotypic and functional alterations. Although single-cell technologies have elucidated age-related compositional changes, prospective identification of aging-associated HSC subsets has remained challenging. In this study, utilizing Clusterin (Clu)-GFP reporter… read more here.
Keywords: age; clu hscs; hematopoietic stem; clu ... See more keywords
Alzheimer’s disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-025-00840-1
Abstract: Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified a plethora of risk loci. However, the disease variants/genes and the underlying mechanisms have not been extensively studied. Bulk ATAC-seq was performed in induced pluripotent… read more here.
Keywords: neuron glia; lipid droplet; clu; protective allele ... See more keywords
Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrils
Sign Up to like & getrecommendations! Published in 2025 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-025-02015-x
Abstract: Accumulating evidence highlights that dysfunction of astrocyte biology might contribute to Parkinson’s disease (PD) onset and progression. Leucine-rich repeat kinase 2 (LRRK2), a gene linked to genetic and familial PD, has been reported to affect… read more here.
Keywords: ability; clu; lrrk2 g2019s; exhibit increased ... See more keywords
Inhibition of Clusterin Represses Proliferation by Inducing Cellular Senescence in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-022-11668-0
Abstract: The outcome of pancreatic ductal adenocarcinoma (PDAC) is unsatisfactory, and the identification of novel therapeutic targets is urgently needed. Clinical studies on the antisense oligonucleotide that targets clusterin (CLU) expression have been conducted and have… read more here.
Keywords: clu; senescence; inducing cellular; cellular senescence ... See more keywords
Increased GPC4 and clusterin associated with insulin resistance in patients with PCOS
Sign Up to like & getrecommendations! Published in 2024 at "Endocrine Connections"
DOI: 10.1530/ec-23-0428
Abstract: The aim of the study was to investigate the changes in serum glypican 4 (GPC4) and clusterin (CLU) levels in patients with polycystic ovary syndrome (PCOS) as well as their correlation with sex hormones and… read more here.
Keywords: clu; insulin resistance; gpc4 clu; serum gpc4 ... See more keywords