Nitric oxide hinders club cell proliferation through Gdpd2 during allergic airway inflammation.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13617
Abstract: Excessive nitric oxide (NO) is often observed in the airways of patients with severe asthma. Here, we show that the NO donor diethylamine NONOate impairs the proliferative capacity of mouse club cells and induces club… read more here.
Keywords: cell; gdpd2; proliferation; club ... See more keywords
Club Cell Secretory Protein in Lung Disease: Emerging Concepts and Potential Therapeutics.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of medicine"
DOI: 10.1146/annurev-med-042921-123443
Abstract: Club cell secretory protein (CCSP), also known as secretoglobin 1A1 (gene name SCGB1A1), is one of the most abundant proteins in the lung, primarily produced by club cells of the distal airway epithelium. At baseline,… read more here.
Keywords: lung; medicine; club cell; ccsp ... See more keywords
Club Cell Loss as a Feature of Bronchiolization in ILD
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.630096
Abstract: Background: Distal airway metaplasia may precede honeycombing in progressive fibrosing interstitial lung disease (ILD). The SCGB1A1+ bronchiolar-specific club cell may play a role in this aberrant regenerative process. Objective: To assess the presence of club… read more here.
Keywords: small airways; club cell; feature bronchiolization;
Recombinant club cell protein 16 (CC16) ameliorates cigarette smoke-induced lung inflammation in a murine disease model of COPD
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DOI: 10.3892/mmr.2018.9216
Abstract: Club cell protein (CC16) is expressed primarily by club cells possesses anti-inflammatory properties and is located in the bronchiolar epithelium. Previous studies have demonstrated that CC16 deficiency is associated with the progression of chronic obstructive… read more here.
Keywords: protein; club; cc16; copd ... See more keywords