Nitric oxide hinders club cell proliferation through Gdpd2 during allergic airway inflammation.
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DOI: 10.1002/2211-5463.13617
Abstract: Excessive nitric oxide (NO) is often observed in the airways of patients with severe asthma. Here, we show that the NO donor diethylamine NONOate impairs the proliferative capacity of mouse club cells and induces club… read more here.
Keywords: cell; gdpd2; proliferation; club ... See more keywords
The traditional Chinese patented medicine Qingke Pingchuan granules alleviate acute lung injury by regenerating club cells
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DOI: 10.1002/pul2.12138
Abstract: Abstract Qingke Pingchuan granules (QKPCG), a patented traditional Chinese medicine, clinically, are recommended for acute tracheobronchitis, cough, community‐acquired pneumonia, and other respiratory diseases. However, its potential protective effect and mechanism of action in acute lung… read more here.
Keywords: qkpcg; medicine; club cells; lung injury ... See more keywords
Culture and Differentiation of Lung Bronchiolar Epithelial Cells In Vitro.
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DOI: 10.1007/978-1-4939-8600-2_4
Abstract: Club cells are a major bronchiolar epithelial cell type in the lung. Using genetic lineage tracing in mice and in vitro culture of purified cells, we have shown that club cells can differentiate into alveolar… read more here.
Keywords: bronchiolar epithelial; vitro culture; club cells; culture ... See more keywords
Effect of light on the calretinin and calbindin expression in skin club cells of adult zebrafish
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DOI: 10.1007/s00418-020-01883-9
Abstract: In the last decade, zebrafish has been used as a model for the study of several human skin diseases. The epidermis of Danio rerio is composed of keratinocytes and two types of secretory cells: mucous… read more here.
Keywords: calretinin calbindin; calretinin; skin club; club cells ... See more keywords
Bacteria evoke alarm behaviour in zebrafish
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DOI: 10.1038/s41467-019-11608-9
Abstract: When injured, fish release an alarm substance (Schreckstoff) that elicits fear in members of their shoal. Although Schreckstoff has been proposed to be produced by club cells in the skin, several observations indicate that these… read more here.
Keywords: alarm substance; substance; club cells; alarm behaviour ... See more keywords
Angiotensin-converting enzyme 2 in peripheral lung club cells modulates the susceptibility to SARS-CoV-2 in chronic obstructive pulmonary disease
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Lung Cellular and Molecular Physiology"
DOI: 10.1152/ajplung.00305.2021
Abstract: Accumulating evidence has confirmed that chronic obstructive pulmonary disease (COPD) is a risk factor for development of severe pathological changes in the peripheral lungs of patients with COVID-19. However, the underlying molecular mechanisms remain unclear.… read more here.
Keywords: obstructive pulmonary; club; chronic obstructive; physiology ... See more keywords
Ontogeny and Biology of Human Small Airway Epithelial Club Cells
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DOI: 10.1164/rccm.201710-2107oc
Abstract: Rationale: Little is known about human club cells, dome‐shaped cells with dense cytoplasmic granules and microvilli that represent the major secretory cells of the human small airways (at least sixth‐generation bronchi). Objectives: To define the… read more here.
Keywords: club; club cells; human small; small airway ... See more keywords
Confocal Identification of Immune Molecules in Skin Club Cells of Zebrafish (Danio rerio, Hamilton 1882) and Their Possible Role in Immunity
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DOI: 10.3390/biology11111653
Abstract: Simple Summary The immune systems of fish can respond rapidly to biological, physical, and environmental stresses and defend the body against pathogens. The skin is the organ most in contact with the external environment and… read more here.
Keywords: immune molecules; cells zebrafish; immune; immune system ... See more keywords