Precision prophylaxis: Identifying the optimal timing for risk-reducing salpingo-oophorectomy based on type of BRCA1 and BRCA2 cluster region mutations.
Sign Up to like & getrecommendations! Published in 2020 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.11.036
Abstract: OBJECTIVES Current risk-reducing salpingo-oophorectomy (RRSO) guidelines for individuals with BRCA1/2 mutations do not account for risk variability due to BRCA1/2 cluster region mutations that are associated with varying risks for the development of breast and… read more here.
Keywords: risk; cluster region; cancer; cluster ... See more keywords
Comparative Expression Analysis of Breakpoint Cluster Region–Abelson Oncogene in Leukemia Patients
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DOI: 10.1021/acsomega.2c07885
Abstract: Leukemia is a proliferative disorder of myeloid and lymphoid cells that may lead to death. Different types of leukemia have been reported, and several genetic and environmental factors are involved in their development. The Philadelphia… read more here.
Keywords: region abelson; breakpoint cluster; leukemia; expression ... See more keywords
Pancreatic cancer cluster region identified in BRCA2
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DOI: 10.1136/jmg-2022-109111
Abstract: Pancreatic cancer has a poor prognosis. Lack of diagnostic markers prevents its early diagnosis and treatment. Pathogenic germline variation in BRCA1 and BRCA2 (BRCA) is genetic predisposition for cancer. The location of variants in different… read more here.
Keywords: pancreatic cancer; cancer cluster; cluster region; cancer ... See more keywords
Geochemical Study of Cretaceous Magmatic Rocks and Related Ores of the Hucunnan Cu–Mo Deposit: Implications for Petrogenesis and Poly-Metal Mineralization in the Tongling Ore-Cluster Region
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DOI: 10.3390/min10020107
Abstract: The Hucunnan porphyry- and skarn-type Cu–Mo deposit is located in the south of the central Shizishan ore field of the Tongling ore-cluster region. The intrusive Hucunnan granodiorite, outcropping in this deposit, has adakitic geochemical features,… read more here.
Keywords: cluster region; deposit; tongling ore; ore cluster ... See more keywords