Candida albicans Zn Cluster Transcription Factors Tac1 and Znc1 Are Activated by Farnesol To Upregulate a Transcriptional Program Including the Multidrug Efflux Pump CDR1
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DOI: 10.1128/aac.00968-18
Abstract: Farnesol, a quorum-sensing molecule, inhibits Candida albicans hyphal formation, affects its biofilm formation and dispersal, and impacts its stress response. Several aspects of farnesol's mechanism of action remain incompletely uncharacterized. ABSTRACT Farnesol, a quorum-sensing molecule,… read more here.
Keywords: tac1 znc1; cluster transcription; candida albicans; cdr1 ... See more keywords
A Hyperactive Form of the Zinc Cluster Transcription Factor Stb5 Causes YOR1 Overexpression and Beauvericin Resistance in Candida albicans
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DOI: 10.1128/aac.01655-18
Abstract: Gain-of-function mutations in the zinc cluster transcription factors Mrr1, Tac1, and Upc2, which result in constitutive overexpression of their target genes, are a frequent cause of fluconazole resistance in the pathogenic yeast Candida albicans. In… read more here.
Keywords: overexpression; zinc cluster; cluster transcription; beauvericin ... See more keywords