Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-022-04398-6
Abstract: Clustered somatic mutations are common in cancer genomes and previous analyses reveal several types of clustered single-base substitutions, which include doublet- and multi-base substitutions1–5, diffuse hypermutation termed omikli6, and longer strand-coordinated events termed kataegis3,7–9. Here… read more here.
Keywords: cancer; base substitutions; clustered mutations; mutational processes ... See more keywords
Examining clustered somatic mutations with SigProfilerClusters
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac335
Abstract: Summary Clustered mutations are found in the human germline as well as in the genomes of cancer and normal somatic cells. Clustered events can be imprinted by a multitude of mutational processes, and they have… read more here.
Keywords: clustered events; clustered somatic; examining clustered; mutations sigprofilerclusters ... See more keywords