Visualization of clustered protocadherin neuronal self-recognition complexes
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.2210/pdb6e6b/pdb
Abstract: Neurite self-recognition and avoidance are fundamental properties of all nervous systems1. These processes facilitate dendritic arborization2,3, prevent formation of autapses4 and allow free interaction among non-self neurons1,2,4,5. Avoidance among self neurites is mediated by stochastic… read more here.
Keywords: clustered protocadherin; avoidance; recognition complexes; recognition ... See more keywords
How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.72416
Abstract: The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms provides diverse identities to individual vertebrate neurons and a molecular basis for self-/nonself-discrimination. cPcdhs form chains mediated by alternating cis and trans interactions between… read more here.
Keywords: recognition; neuronal self; clustered protocadherin; specificity ... See more keywords