Novel insight into the role of clusterin on intraocular pressure regulation by modifying actin polymerization and extracellular matrix remodeling in the trabecular meshwork
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30769
Abstract: This study provides comprehensive mechanistic evidence for the role of clusterin, a stress‐response secretory chaperone protein, in the modulation of intraocular pressure (IOP) by regulating the trabecular meshwork (TM) actin cytoskeleton and the extracellular matrix… read more here.
Keywords: clusterin; actin polymerization; regulation; protein ... See more keywords
Pharmacokinetic determinants of cisplatin-induced subclinical kidney injury in oncology patients
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2552-z
Abstract: PurposeThe ability to predict and detect clinical and subclinical nephrotoxicity early in the course of therapy has the potential to improve long-term outcomes in cancer patients receiving cisplatin chemotherapy. Pharmacokinetic parameters could serve as predictors… read more here.
Keywords: kidney injury; platinum; clusterin; cisplatin induced ... See more keywords
Urinary clusterin—a novel urinary biomarker associated with pediatric lupus renal histopathologic features and renal survival
Sign Up to like & getrecommendations! Published in 2018 at "Pediatric Nephrology"
DOI: 10.1007/s00467-018-3924-4
Abstract: BackgroundLupus nephritis (LN) is a major risk factor for systemic lupus erythematous (SLE)-related morbidity and mortality. With the aim of bypassing renal biopsy, we analyzed urinary biomarkers for their ability to predict renal histopathologic features… read more here.
Keywords: renal histopathologic; clusterin; urinary clusterin; lupus ... See more keywords
Toll-like receptor 4 signaling is required for clusterin-induced tumor necrosis factor-α secretion in macrophage.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.12.049
Abstract: Clusterin is a secretory glycoprotein that is up-regulated in areas of inflammation and under increased levels of oxidative stress. Previously, we demonstrated that clusterin activates NF-κB, and up-regulates the expression of MMP-9 and TNF-α. In… read more here.
Keywords: secretion; clusterin; macrophage; clusterin induced ... See more keywords
Colorimetric Aptasensor for the Visual and Microplate Determination of Clusterin in Human Urine Based on Aggregation Characteristics of Gold Nanoparticles
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c08040
Abstract: Clusterin has the potential to become the biomarker of multiple diseases, but its clinical quantitative detection methods are limited, which restricts its research progress as a biomarker. A rapid and visible colorimetric sensor for clusterin… read more here.
Keywords: aggregation; clusterin; human urine; gold nanoparticles ... See more keywords
Divergent roles for Clusterin in Lung Injury and Repair
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DOI: 10.1038/s41598-017-15670-5
Abstract: Lung fibrosis is an unabated wound healing response characterized by the loss and aberrant function of lung epithelial cells. Herein, we report that extracellular Clusterin promoted epithelial cell apoptosis whereas intracellular Clusterin maintained epithelium viability… read more here.
Keywords: epithelial cell; extracellular clusterin; divergent roles; clusterin ... See more keywords
Clusterin expression in non-tumor tissue in patients with resectable hepatocellular carcinoma related with post-resectional survival.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Chinese Medical Association"
DOI: 10.1097/jcma.0000000000000195
Abstract: BACKGROUND Surgical resection offers an effective treatment for patients with hepatocellular carcinoma (HCC); however, it has high tumor recurrence rate. Clusterin is a highly conserved glycoprotein that enhances cell aggregation in vitro. It is upregulated… read more here.
Keywords: non tumor; tissue; clusterin expression; tumor ... See more keywords
Clusterin is increased in morphologically normal cardiomyocytes in lymphocytic myocarditis
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Clinical Investigation"
DOI: 10.1111/eci.13905
Abstract: Myocarditis is an inflammatory disease of the heart that is most commonly caused by a viral infection of the heart. Infections with cardiotropic viruses result in lymphocytic myocarditis (LM), characterized by infiltration in majority of… read more here.
Keywords: myocarditis; clusterin; lymphocytic myocarditis; normal cardiomyocytes ... See more keywords
P091 Clusterin is increased in early rheumatoid arthritis and predicts disease activity and treatment response
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-ewrr2018.107
Abstract: Introduction Clusterin (apolipoprotein J) is a molecular chaperone involved in a number of biological processes, such as inflammation and apoptosis. Recent data suggest its role in the development of autoimmune diseases and bone erosions. Objectives… read more here.
Keywords: clusterin; disease activity; activity; treatment response ... See more keywords
The Influence of Clusterin Glycosylation Variability on Selected Pathophysiological Processes in the Human Body
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/7657876
Abstract: The present review gathers together the most important information about variability in clusterin molecular structure, its profile, and the degree of glycosylation occurring in human tissues and body fluids in the context of the utility… read more here.
Keywords: clusterin; selected pathophysiological; variability; glycosylation ... See more keywords
Clusterin modulates transdifferentiation of non-small-cell lung cancer
Sign Up to like & getrecommendations! Published in 2017 at "BMC Cancer"
DOI: 10.1186/s12885-017-3649-y
Abstract: BackgroundSecreted clusterin (sCLU), a 75–80 kDa disulfide-linked heterodimeric protein, plays crucial roles in various pathophysiological processes, including lipid transport, tissue remodeling, cell apoptosis and reproduction. Our previous studies demonstrated that sCLU could influence cell apoptosis, proliferation,… read more here.
Keywords: clusterin; cell; transdifferentiation; lung cancer ... See more keywords