Sublytic Activity of a Pore‐Forming Protein From Commensal Bacteria Causes Epigenetic Modulation of Tumour‐Affiliated Protein Expression
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.70149
Abstract: ABSTRACT Cytolysin A (ClyA) is a pore‐forming protein from a strongly silenced gene in non‐pathogenic Escherichia coli, including typical commensal isolates in the intestinal microbiome of healthy mammalian hosts. Upon overproduction, ClyA‐expressing bacteria display a… read more here.
Keywords: pore forming; clya; commensal; protein ... See more keywords
Preparation of Cytolysin A (ClyA) Nanopores.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0806-7_2
Abstract: The ionic currents passing through nanopores can be used to sequence DNA and identify molecules at the single-molecule level. Recently, researchers have started using nanopores for the detection and analysis of proteins, providing a new… read more here.
Keywords: preparation cytolysin; clya nanopores; clya; enzymology ... See more keywords
Cytolysin A (ClyA): A Bacterial Virulence Factor with Potential Applications in Nanopore Technology, Vaccine Development, and Tumor Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14020078
Abstract: Cytolysin A (ClyA) is a pore-forming toxin that is produced by some bacteria from the Enterobacteriaceae family. This review provides an overview of the current state of knowledge regarding ClyA, including the prevalence of the… read more here.
Keywords: cytolysin clya; vaccine development; clya; potential applications ... See more keywords
Enhancing photothermal therapy of tumors with image-guided thermal control of gene-expressing bacteria
Sign Up to like & getrecommendations! Published in 2024 at "Theranostics"
DOI: 10.7150/thno.98257
Abstract: Purpose: Bacteria-mediated tumor therapy has showed promising potential for cancer therapy. However, the efficacy of bacterial monotherapy treatment which can express and release therapeutic proteins in tumors has been found to be unsatisfactory. To date,… read more here.
Keywords: therapy; clya; tumor; cgb icg ... See more keywords