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   Articles with "clz" as a keyword



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Clozapine impact on c‐Fos expression in mild stress preconditioned male rats exposed to a novelty stressor

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recommendations! Published in 2018 at "Journal of Neuroscience Research"

DOI: 10.1002/jnr.24280

Abstract: Clozapine (CLZ) stimulates several brain areas some of them being sensitive to stress. Aim of the present study was to reveal whether 7‐day CLZ administration may: (1) activate the selected forebrain areas; (2) modulate response… read more here.

Keywords: response; clz; vehicle clz; stress ... See more keywords
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Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeability

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recommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"

DOI: 10.1016/j.ejps.2017.11.004

Abstract: ABSTRACT The use of polymeric nanoparticles as delivery systems is a promising tool to overcome drawbacks related to low aqueous solubility of drugs, which limit their in vivo bioavailability. The aim of this study was… read more here.

Keywords: plga nanoparticles; clz; nps clz; oral delivery ... See more keywords
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CLZ-8, a potent small-molecular compound, protects radiation-induced damages both in vitro and in vivo.

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recommendations! Published in 2018 at "Environmental toxicology and pharmacology"

DOI: 10.1016/j.etap.2018.05.004

Abstract: PUMA (p53 up-regulated mediator of apoptosis) is particularly important in initiating radiation-induced damage and apoptosis. It has been shown that inhibition of PUMA can provide a profound benefit for the long-term survival of the mice,… read more here.

Keywords: apoptosis; clz; radiation induced; puma ... See more keywords
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Longitudinal effects of clozapine concentration and clozapine to N-desmethylclozapine ratio on cognition: A mediation model

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recommendations! Published in 2020 at "European Neuropsychopharmacology"

DOI: 10.1016/j.euroneuro.2020.01.016

Abstract: Previous cross-sectional studies have found clozapine to N-desmethylclozapine (CLZ:NDMC) ratio to be negatively correlated with cognition in clozapine-treated patients with schizophrenia. However, no work has examined the association between CLZ:NDMC ratio and cognition using a… read more here.

Keywords: clz ndmc; clz; ratio cognition; ndmc ratio ... See more keywords
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Clorazepate removal from aqueous solution by adsorption onto maghnite: Experimental and theoretical analysis

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recommendations! Published in 2021 at "Journal of Molecular Liquids"

DOI: 10.1016/j.molliq.2021.115430

Abstract: Abstract The removal of a benzodiazepine (clorazepate, CLZ) from aqueous solution by adsorption onto maghnite clay is investigated supported by theoretical simulations. The Fourier-transform infrared (FTIR), Ultraviolet (UV), X-ray diffraction (XRD), and scanning electron microscope… read more here.

Keywords: clz; onto maghnite; adsorption onto; aqueous solution ... See more keywords
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The antidepressant- and anxiolytic-like effects of fluoxetine and clozapine in chronically isolated rats involve inhibition of hippocampal TNF-α

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recommendations! Published in 2017 at "Pharmacology Biochemistry and Behavior"

DOI: 10.1016/j.pbb.2017.10.006

Abstract: Abstract Brain oxidative stress and neuroinflammation are implicated in psychiatric disorders. Thus, it is important to investigate the effects of individual psychotropic agents on antioxidative defense and proinflammatory mediators in brain regions associated with these… read more here.

Keywords: clozapine; clz; tnf agr; csis ... See more keywords
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Carbohydrate-Derived Polytriazole Nanoparticles Enhance the Anti-Inflammatory Activity of Cilostazol

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c02969

Abstract: Poly(amide-triazole) and poly(ester-triazole) synthesized from d-galactose as a renewable resource were applied for the synthesis of nanoparticles (NPs) by the emulsification/solvent evaporation method. The NPs were characterized as stable, spherical particles, and none of their… read more here.

Keywords: cilostazol; carbohydrate derived; clz; anti inflammatory ... See more keywords
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Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits

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recommendations! Published in 2020 at "Translational Psychiatry"

DOI: 10.1038/s41398-020-00888-1

Abstract: Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic variability. Here, we conducted a genome-wide association study (GWAS) of CLZ serum concentration adjusting for known smoking habits,… read more here.

Keywords: clz; serum; smoking habits; association ... See more keywords
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Proniosomes as a carrier system for transdermal delivery of clozapine

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recommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"

DOI: 10.1080/03639045.2020.1764020

Abstract: Abstract The current study aimed to formulate the clozapine (CLZ) loaded proniosomal (PN) gel and evaluate its in vitro release, ex vivo permeation and gel properties. CLZ is a BCS class II drug with low… read more here.

Keywords: clozapine; clz; delivery; proniosomes carrier ... See more keywords
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Effect of sulfobutyl ether-β-cyclodextrin and propylene glycol alginate on the solubility of clozapine

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recommendations! Published in 2019 at "Pharmaceutical Development and Technology"

DOI: 10.1080/10837450.2018.1514521

Abstract: Abstract Clozapine (CLZ) is an atypical antipsychotic medication used in the treatment of schizophrenia and is poorly soluble in water (0.05 mM). In this study, we have investigated the effect of β-cyclodextrin (CD) and its derivatives… read more here.

Keywords: clz; solubility clz; sulfobutyl ether; effect ... See more keywords
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M138. THE STRUCTURAL AND FUNCTIONAL BRAIN IMPACT OF CLOZAPINE IN SCHIZOPHRENIC PATIENTS: REVIEW OF THE LITERATURE

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recommendations! Published in 2020 at "Schizophrenia Bulletin"

DOI: 10.1093/schbul/sbaa030.450

Abstract: Abstract Background Schizophrenia is a common and severe mental disorder. The actual treatment is neuroleptic. Clozapine (CLZ), the atypical antipsychotic leader, is the best treatment of the resistant schizophrenia. Neuroimaging studies are important to understand… read more here.

Keywords: schizophrenia; clz; treatment; functional brain ... See more keywords