Effect of age and renal impairment on the pharmacokinetics and safety of trimetazidine: An open-label multiple-dose study.
Sign Up to like & getrecommendations! Published in 2020 at "Drug development research"
DOI: 10.1002/ddr.21654
Abstract: This study evaluated the effect of age and renal impairment on pharmacokinetics of trimetazidine (TMZ) in healthy elderly and renally impaired subjects and assess safety and tolerability. In this open-label, multi-dose study, 73 subjects were… read more here.
Keywords: age; group auc; study; renally impaired ... See more keywords
Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00632
Abstract: Structure-property relationships associated with a series of (carbonyl)oxyalkyl amino acid ester prodrugs of the marketed HIV-1 protease inhibitor atazanavir (1), designed to enhance the systemic drug delivery, were examined. Compared to previously reported prodrugs, optimized… read more here.
Keywords: carbonyl oxyalkyl; prodrug activation; cmax; drug delivery ... See more keywords
Large Intra-subject Variability in Caffeine Pharmacokinetics: Randomized Cross-over Study of Single Caffeine Product.
Sign Up to like & getrecommendations! Published in 2017 at "Drug research"
DOI: 10.1055/s-0043-110144
Abstract: Background Average bioequivalence has been criticized for not adequately addressing individual variations. Importance of subjects' blinding in bioequivalence studies has not been well studied. We explored the extent of intra-subject pharmacokinetic variability and effect of… read more here.
Keywords: bioequivalence; caffeine; caffeine product; intra subject ... See more keywords
Pharmacokinetics of Co-encapsulated Antiretrovirals with Ingestible Sensors.
Sign Up to like & getrecommendations! Published in 2019 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2019.0202
Abstract: We investigated the use of a system with an ingestible sensor (Proteus Digital Health Feedback system) co-encapsulated with antiretrovirals (ARVs) to measure real-time adherence. To assess the safety and impact, if any, co-encapsulation might have… read more here.
Keywords: encapsulated antiretrovirals; cmax; auc; ftc ... See more keywords
Gentamicin Administration in Dialysis Patients: Before or After Hemodialysis?
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic drug monitoring"
DOI: 10.1097/ftd.0000000000001058
Abstract: BACKGROUND Gentamicin is used to treat severe infections and has a small therapeutic window. This study aimed to optimize the dosing strategy of gentamicin in intermittently hemodialyzed patients by simulating concentration/time profiles during pre- and… read more here.
Keywords: cmax auc24h; gentamicin administration; cmax; dialysis ... See more keywords
Effects of genotype and food on naltrexone exposure in adolescents
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DOI: 10.1111/cts.13399
Abstract: Naltrexone (NTX), an opioid antagonist metabolized by aldo‐keto reductase 1C4 (AKR1C4), is prescribed for psychiatric conditions like eating disorders with variable response. Systemic exposure is highly variable in adults, yet no data exist in children.… read more here.
Keywords: exposure adolescents; eating disorders; cmax; genotype food ... See more keywords
Finding Tmax and Cmax in Multicompartmental Models
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.118.082636
Abstract: Drug absorption data are critical in bioequivalence comparisons, and factors such as the maximum drug concentration (Cmax), time to achieve Cmax (or Tmax), as well as the area under the curve (AUC) are important metrics.… read more here.
Keywords: absorption; method; tmax cmax; cmax multicompartmental ... See more keywords