Plin5/p-Plin5 Guards Diabetic CMECs by Regulating FFAs Metabolism Bidirectionally
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/8690746
Abstract: Background Hyper-free fatty acidemia (HFFA) impairs cardiac capillaries, as well as type 2 diabetes mellitus (T2DM). Perilipin 5 (Plin5) maintains metabolic balance of free fatty acids (FFAs) in high oxidative tissues via the states of… read more here.
Keywords: cmecs regulating; regulating ffas; diabetic cmecs; ffas metabolism ... See more keywords
Oxidative-Damaged Mitochondria Activate GABARAPL1-Induced NLRP3 Inflammasomes in an Autophagic-Exosome Manner after Acute Myocardial Ischemia
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DOI: 10.1155/2022/7958542
Abstract: Objective This study is aimed at identifying the potential diagnostic markers for circulating endothelial cells (CECs) for acute myocardial ischemia (AMI) and exploring the regulatory mechanisms of the selected biomarker in mitochondrial oxidative damage and… read more here.
Keywords: cmecs; cecs; damaged mitochondria; ami ... See more keywords
Advanced glycation end products facilitate the proliferation and reduce early apoptosis of cardiac microvascular endothelial cells via PKCβ signaling pathway: Insight from diabetic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2020 at "Anatolian Journal of Cardiology"
DOI: 10.14744/anatoljcardiol.2019.21504
Abstract: Objective: To investigate the effects of advanced glycation end products (AGEs) on the proliferation and apoptosis of cardiac microvascular endothelial cells (CMECs) in rats and their underlying signaling pathway. Methods: CMECs were isolated from Sprague–Dawley… read more here.
Keywords: early apoptosis; apoptosis; proliferation; pkc ... See more keywords
Substance-P Inhibits Cardiac Microvascular Endothelial Dysfunction Caused by High Glucose-Induced Oxidative Stress
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DOI: 10.3390/antiox10071084
Abstract: Diabetes is characterized by high glucose (HG) levels in the blood circulation, leading to exposure of the vascular endothelium to HG conditions. Hyperglycemia causes oxidative stress via excessive reactive oxygen species (ROS) production in the… read more here.
Keywords: dysfunction; high glucose; cmecs; cardiac microvascular ... See more keywords