Elucidating the mechanism underlying cognitive dysfunction by investigating the effects of CMF and MET treatment on hippocampal neurons.
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DOI: 10.26355/eurrev_202202_27981
Abstract: OBJECTIVE Chemotherapy causes long-term cognitive impairment in cancer survivors. A combination of cyclophosphamide (CYP), methotrexate (MTX), and 5-fluorouracil (5-FU) (i.e., CMF) is widely used for cancer treatment. Metformin (MET), an oral antidiabetic drug, confers protection… read more here.
Keywords: lipid peroxidation; met treated; treated cells; cmf ... See more keywords
Effects of CMF and MET on glutamate and dopamine levels in the brain, and their impact on cognitive function.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202204_28465
Abstract: OBJECTIVE Chemotherapy can cause cognitive impairment in cancer survivors. CMF, the combination of cyclophosphamide (CYP), methotrexate (MTX), and 5-fluorouracil (5-FU), is employed for the treatment of several types of cancers, such as metastatic breast cancer.… read more here.
Keywords: cmf met; glutamate dopamine; brain; dopamine levels ... See more keywords