Characterization of the dimeric CMG/pre-initiation complex and its transition into DNA replication forks
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03333-9
Abstract: The pre-initiation complex (pre-IC) has been proposed for two decades as an intermediate right before the maturation of the eukaryotic DNA replication fork. However, its existence and biochemical nature remain enigmatic. Here, through combining several… read more here.
Keywords: dimeric cmg; cmg; initiation; dna ... See more keywords
Evaluation of a Magnetic Gear for Air-Cooled Condenser Applications
Sign Up to like & getrecommendations! Published in 2018 at "Iet Electric Power Applications"
DOI: 10.1049/iet-epa.2017.0714
Abstract: In high-power industrial applications such as air-cooled condenser fans, excessive mechanical gear failures highlight a need to investigate possible alternatives. In this study, the concentric magnetic gear (CMG) is evaluated as a potential replacement for… read more here.
Keywords: cmg; cooled condenser; magnetic gear; air cooled ... See more keywords
Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1819107116
Abstract: Significance Fork regression is a way of circumventing or dealing with DNA lesions and is important to genome integrity. Fork regression is performed by double-strand DNA ATPases that initially cause newly synthesized strands to unpair… read more here.
Keywords: cmg; regression; dna; fork regression ... See more keywords
CMG helicase can use ATPγS to unwind DNA: Implications for the rate-limiting step in the reaction mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2119580119
Abstract: Significance The rate-limiting step of hexameric replicative helicases is ill-understood and this study on the eukaryotic replicative helicase CMG identifies that the catalytic ATP hydrolysis step is not the rate-limiting step, implying that a conformational… read more here.
Keywords: cmg; step; dna; rate limiting ... See more keywords
Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1101/2022.12.23.521684
Abstract: Here the authors examine fully reconstituted and activated CMG helicases at the single-molecule level. They observe unidirectional translocation by CMG in ATP and diffusive motion by CMG without ATP, where the latter can be halted… read more here.
Keywords: cmg; diffusion; dna; motion ... See more keywords
Health Indicator Construction of High-Speed Rotating Bearings in Aerospace CMG Based on Physics-Inspired Machine-Learning Approach
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Instrumentation and Measurement"
DOI: 10.1109/tim.2022.3208253
Abstract: Control moment gyro (CMG) is a critical component for attitude control of large spacecraft. To avoid its accidental failure caused by the performance degradation of high-speed rotating bearings, a metric, which is referred to as… read more here.
Keywords: high speed; cmg; physics; physics inspired ... See more keywords
Investigation of the Torque Transmission Characteristics in Dual-Flux-Modulated Magnetic Gear
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Transactions on Magnetics"
DOI: 10.1109/tmag.2020.3021644
Abstract: Due to the field-modulation effect, the coaxial magnetic gear (CMG) can achieve a low-speed high-torque transmission. To further improve the torque capability, a dual-flux-modulated CMG (DFM-CMG) derived from conventional CMGs is presented. The DFM-CMG has… read more here.
Keywords: dfm cmg; magnetic gear; torque; cmg ... See more keywords
Multi-Objective Optimization for a Dual-Flux-Modulator Coaxial Magnetic Gear With Double-Layer Permanent Magnet Inner Rotor
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Magnetics"
DOI: 10.1109/tmag.2021.3065464
Abstract: To improve the torque capability and permanent magnets (PMs) utilization efficiency of the dual-flux-modulator coaxial magnetic gear (DFM-CMG), a double-layer PMs (DLPM) layout on the inner rotor (IR) is proposed. In this article, the torque… read more here.
Keywords: dfm cmg; flux modulator; layer; cmg ... See more keywords
Abstract C014: Development of an injectable water-soluble anticancer drug CMG for oxaliplatin-resistant colorectal cancer with KRAS mutation
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-c014
Abstract: Recent well-designed preclinical studies have demonstrated that KRAS mutations can activate the canonical NF-κB signaling pathway, which is a pivotal role in tumor progression. Therefore, inhibition of this KRAS-NF-κB axis would be a promising target… read more here.
Keywords: cancer; water soluble; cmg oxaliplatin; colorectal cancer ... See more keywords
Abstract 2909: Development of new mechanism based therapeutic antibodies in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2909
Abstract: Lung cancer is second most common cancer in the world. Non Small Cell Lung Cancer (NSCLC) accounts approximately 80-85% of all lung cancer diagnosis. Traditional therapies of this disease were surgical resection, chemotherapy, and radiotherapy,… read more here.
Keywords: cmg; antibody; lung cancer; cancer ... See more keywords
Flux modulated rotating pole piece magnetic gear
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Power Electronics and Drive Systems"
DOI: 10.11591/ijpeds.v11.i4.pp1731-1736
Abstract: In this paper, the CMG is re-condition so that the pole piece act as the outer rotor instead of surface mount PM. This magnetic coupling of the CMG is similar to the conventional CMG which… read more here.
Keywords: pole piece; flux modulated; modulated rotating; gear ... See more keywords