Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab799
Abstract: Genomic DNA replication requires replisome assembly. We show here the molecular mechanism by which CMG (GAN-MCM-GINS)-like helicase cooperates with the family D DNA polymerase (PolD) in Thermococcus kodakarensis. The archaeal GINS contains two Gins51 subunits,… read more here.
Keywords: family dna; dna; dna polymerase; helicase ... See more keywords
CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.60371
Abstract: The eukaryotic replisome assembles around the CMG helicase, which stably associates with DNA replication forks throughout elongation. When replication terminates, CMG is ubiquitylated on its Mcm7 subunit and disassembled by the Cdc48/p97 ATPase. Until now,… read more here.
Keywords: dna; ubiquitin threshold; replication; cmg helicase ... See more keywords