Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-018-2944-3
Abstract: The adipokine Chemerin and its receptor, chemokine-like receptor 1 (CMKLR1), are associated with osteoblastogenic differentiation of mesenchymal stem cells (MSCs) and osteoclastogenic differentiation of osteoclast precursors in vitro, suggesting that CMKLR1 would affect the bone… read more here.
Keywords: cmklr1; male mice; bone; bone mass ... See more keywords
Chemerin/CMKLR1 Axis Promotes the Progression of Proliferative Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Endocrinology"
DOI: 10.1155/2021/4468625
Abstract: Background Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes, and the levels of chemerin were associated with the severity of DR. However, there is no research on chemerin in the development of proliferative… read more here.
Keywords: chemerin cmklr1; chemerin; diabetic retinopathy; pdr ... See more keywords
The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.154440
Abstract: Gastrointestinal graft-versus-host disease (GvHD) is a major cause of mortality and morbidity following allogeneic bone marrow transplantation (allo-BMT). Chemerin is a chemotactic protein that recruits leukocytes to inflamed tissues by interacting with ChemR23/CMKLR1, a chemotactic… read more here.
Keywords: chemerin; gvhd; mice; graft versus ... See more keywords
Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.985618
Abstract: Endometriosis is a common gynecological disease, characterized by the presence of endometrial-like lesions outside the uterus. This debilitating disease causes chronic pelvic pain and infertility with limited therapeutics. Chemerin is a secretory protein that acts… read more here.
Keywords: cmklr1 axis; small molecule; molecule antagonist; endometriosis ... See more keywords
Chemerin and Chemokine-like Receptor 1 Expression in Ovarian Cancer Associates with Proteins Involved in Estrogen Signaling
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13050944
Abstract: Chemerin, a pleiotropic adipokine coded by the RARRES2 gene, has been reported to affect the pathophysiology of various cancer entities. To further approach the role of this adipokine in ovarian cancer (OC), intratumoral protein levels… read more here.
Keywords: ovarian cancer; chemerin; expression; receptor ... See more keywords
Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19102905
Abstract: Chemerin (also known as tazarotene-induced gene 2 and retinoic acid receptor responder 2) has been identified as an adipokine that exerts effects on many biological processes, including adipogenesis, angiogenesis, inflammation, immune responses, and food intake.… read more here.
Keywords: cmklr1; chemerin cmklr1; nutritional status; expression ... See more keywords
Simvastatin inhibits the adipogenesis of bone marrow-derived mesenchymal stem cells through the downregulation of chemerin/CMKLR1 signaling
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2020.4606
Abstract: Simvastatin is effective in the treatment of osteoporosis, partly through the inhibition of the adipogenesis of bone-marrow derived mesenchymal stem cells (BMSCs). The present study focused on the mechanisms responsible for the inhibitory effects of… read more here.
Keywords: cmklr1 signaling; cmklr1; chemerin cmklr1; adipogenesis ... See more keywords