Epithelial chemerin–CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205574119
Abstract: Significance Epithelial antimicrobial defense is an important innate mechanism to maintain intestinal homeostasis and closely involved in the pathogenesis of inflammatory bowel disease (IBD). Chemerin, which is abundantly expressed in barrier tissues, regulates tissue inflammation… read more here.
Keywords: chemerin cmklr1; chemerin; cmklr1 signaling; microbiota driven ... See more keywords
Simvastatin inhibits the adipogenesis of bone marrow-derived mesenchymal stem cells through the downregulation of chemerin/CMKLR1 signaling
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DOI: 10.3892/ijmm.2020.4606
Abstract: Simvastatin is effective in the treatment of osteoporosis, partly through the inhibition of the adipogenesis of bone-marrow derived mesenchymal stem cells (BMSCs). The present study focused on the mechanisms responsible for the inhibitory effects of… read more here.
Keywords: cmklr1 signaling; cmklr1; chemerin cmklr1; adipogenesis ... See more keywords