Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK‐ERK and NF‐κB pathways in a model of chronic myeloid leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12186
Abstract: The introduction of tyrosine kinase inhibitors (TKI) has transformed chronic myeloid leukemia (CML) into a chronic disease with long‐term survival exceeding 85%. However, resistance of CML stem cells to TKI may contribute to the 50%… read more here.
Keywords: cml; myeloid leukemia; tpl2; resistance ... See more keywords
Chronic myeloid leukemia without major molecular response after 2 years of treatment with tyrosine kinase inhibitor
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26836
Abstract: Achieving major molecular response (MMR) with BCR::ABL1 tyrosine kinase inhibitors (TKIs) is associated with lower chances of progression to advanced phase disease and higher chances of treatment‐free remission (TFR) in patients with chronic myeloid leukemia… read more here.
Keywords: year; cml; major molecular; treatment ... See more keywords
Asciminib vs bosutinib in CML patients pretreated with ≥2 tyrosine kinase inhibitors: Results from the Japanese subgroup analysis of ASCEMBL study
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5212
Abstract: Asciminib, a first‐in‐class, allosteric inhibitor of BCR‐ABL1 that acts by STAMP (Specifically Targeting the ABL Myristoyl Pocket), is a novel therapeutic option for patients with chronic myeloid leukemia (CML). In the global, phase 3, open‐label… read more here.
Keywords: ascembl study; cml; subgroup analysis; study ... See more keywords
Selective and effective targeting of chronic myeloid leukemia stem cells by topoisomerase II inhibitor etoposide in combination with imatinib mesylate in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology International"
DOI: 10.1002/cbin.10686
Abstract: Imatinib mesylate (IM) and other BCR‐ABL tyrosine kinase inhibitors (TKIs) have improved chronic myeloid leukemia (CML) patient survival markedly but fail to eradicate quiescent CML leukemia stem cells (LSCs). Thus, strategies targeting LSCs are required… read more here.
Keywords: cml; leukemia; chronic myeloid; stem ... See more keywords
Alkynylnicotinamide‐Based Compounds as ABL1 Inhibitors with Potent Activities against Drug‐Resistant CML Harboring ABL1(T315I) Mutant Kinase
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DOI: 10.1002/cmdc.201700829
Abstract: The introduction of imatinib into the clinical scene revolutionized the treatment of chronic myelogenous leukemia (CML). The overall eight‐year survival rate for CML has increased from about 6 % in the 1970s to over 90 % in… read more here.
Keywords: abl1 t315i; cml; kinase; drug resistant ... See more keywords
Greater Carboxy‐Methyl‐Lysine Is Associated With Increased Fracture Risk in Type 2 Diabetes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4466
Abstract: Accumulation of advanced glycation end‐products (AGE) in bone alters collagen structure and function. Fluorescent AGEs are associated with fractures but less is known regarding non‐fluorescent AGEs. We examined associations of carboxy‐methyl‐lysine (CML), with incident clinical… read more here.
Keywords: risk; cml; methyl lysine; fracture ... See more keywords
Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo
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DOI: 10.1007/s00277-019-03713-y
Abstract: Efficient and safe delivery of siRNA in vivo is the biggest roadblock to clinical translation of RNA interference (RNAi)-based therapeutics. To date, lipid nanoparticles (LNPs) have shown efficient delivery of siRNA to the liver; however,… read more here.
Keywords: oncogene; cml; vivo; delivery sirna ... See more keywords
A multicenter retrospective evaluation of Chronic Myeloid Leukemia (CML) therapy in Austria assessing the impact of early treatment response on patient outcomes in a real-life setting
Sign Up to like & getrecommendations! Published in 2020 at "Wiener Klinische Wochenschrift"
DOI: 10.1007/s00508-020-01690-1
Abstract: Background Several clinical trials in chronic phase (CP) chronic myeloid leukemia (CML) showed that early response to tyrosine kinase inhibitor (TKI) treatment results in an improved long-term survival and progression-free survival. This study assessed whether… read more here.
Keywords: cml; response; treatment; therapy ... See more keywords
Influence of genetic polymorphisms in glutathione-S-transferases gene in response to imatinib among Brazilian patients with chronic myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-020-06093-z
Abstract: Polymorphism in metabolizing enzymes can influence drug response as well as the risk for adverse drug reactions. Nevertheless, there are still few studies analyzing the consequence of polymorphisms for the Glutathione-S-transferases (GST) gene to drug… read more here.
Keywords: cml patients; cml; response; response imatinib ... See more keywords
The Hidden Pathogenesis of CML: Is BCR-ABL1 the First Event?
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DOI: 10.1007/s11899-019-00549-1
Abstract: Identification of the BCR-ABL1 fusion oncogene in patients diagnosed with chronic myeloid leukemia (CML) led to the development of targeted therapy responsible for the dramatic survival benefits observed in the past two decades. However, despite… read more here.
Keywords: bcr; cml; hidden pathogenesis; event ... See more keywords
What Do We Currently Know About Chronic Myeloid Leukemia (CML) and COVID-19?
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DOI: 10.1007/s11912-021-01169-w
Abstract: COVID-19 is highly contagious; since it was first identified, the virus has rapidly spread to more than 100 countries and was declared a pandemic on March 11, 2020, by the World Health Organization (WHO). This… read more here.
Keywords: cml covid; covid; cml; myeloid leukemia ... See more keywords