MicroRNA-153-3p enhances the sensitivity of chronic myeloid leukemia cells to imatinib by inhibiting B-cell lymphoma-2-mediated autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Human Cell"
DOI: 10.1007/s13577-020-00367-1
Abstract: Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease caused by abnormal DNA replication of bone marrow stem cells and chemotherapy resistance is a major obstacle to the effective treatment of patients with CML.… read more here.
Keywords: resistant cml; cml; cml cells; mir 153 ... See more keywords
Cyclic AMP (cAMP) confers drug resistance against DNA damaging agents via PKAIA in CML cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2016.11.043
Abstract: &NA; Cyclic adenosine monophosphate (cAMP) regulates many vital functions such as metabolism, proliferation, differentiation and death. Depending on cell types and stimulators, cAMP could either promote or attenuate cell death. cAMP signal can be transduced… read more here.
Keywords: cml cells; dna damaging; camp; damaging agents ... See more keywords
p53 modulates the effect of ribosomal protein S6 kinase1 (S6K1) on cisplatin toxicity in chronic myeloid leukemia cells
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2017.03.004
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Chronic myeloid leukemia (CML) is characterized by the expression of the oncoprotein, BCR‐ABL. BCR‐ABL inhibitors revolutionized CML chemotherapy while blast crisis (BC) CML patients are less responsive. Since… read more here.
Keywords: cml cells; p53; cml; cisplatin toxicity ... See more keywords
Targeting HSPA8 inhibits proliferation via downregulating BCR-ABL and enhances chemosensitivity in imatinib-resistant chronic myeloid leukemia cells.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112708
Abstract: The resistance to tyrosine kinase inhibitors is currently a major problem for chronic myeloid leukemia (CML) treatment and HSPA8 is highly expressed and a hallmark of poor prognosis in several human cancers. However, its role… read more here.
Keywords: cml; cml cells; proliferation; bcr abl ... See more keywords
Restoration of miR-23a expression by chidamide sensitizes CML cells to imatinib treatment with concomitant downregulation of CRYAB
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2056322
Abstract: ABSTRACT MicroRNAs (miRNAs) are involved in various processes from the initiation and development of cancers, including chronic myeloid leukemia (CML). In this report, we aimed to investigate the roles of miR-23a in the regulation of… read more here.
Keywords: cml cells; cells imatinib; expression; 23a expression ... See more keywords
Characterizing the role of pulmonary veins in pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734519
Abstract: Pulmonary veins (PVs) transport oxygenated blood from lungs back to the heart. Small PVs can play a crucial role in the pathogenesis of pulmonary hypertension. Studies have also shown PV remodeling in pulmonary hypertension and… read more here.
Keywords: pulmonary veins; pulmonary hypertension; cml cells; physiology ... See more keywords
MiR-199a-3p Overexpression Suppressed Cell Proliferation and Sensitized Chronic Myeloid Leukaemia Cells to Imatinib by Inhibiting mTOR Signalling
Sign Up to like & getrecommendations! Published in 2022 at "Acta Haematologica"
DOI: 10.1159/000524158
Abstract: Introduction: Chronic myeloid leukaemia (CML) is a myeloproliferative neoplasm characterized by constitutive activity of the tyrosine kinase BCR-ABL1. Drug resistance remains one of the major challenges in CML therapy. MicroRNA (miR)-199a-3p plays an important role… read more here.
Keywords: cell; cml cells; proliferation; mir 199a ... See more keywords
Immature CML cells implement a BMP autocrine loop to escape TKI treatment
Sign Up to like & getrecommendations! Published in 2018 at "Translational cancer research"
DOI: 10.21037/22385
Abstract: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder emanating from a reciprocal translocation between BCR on chromosome 22 and ABL kinase on chromosome 9, generally known as the Philadelphia chromosome. Although activity level of… read more here.
Keywords: cml; cml cells; immature cml; cells implement ... See more keywords