Spectrum of renal pathological findings in patients with chronic myelomonocytic leukemia and kidney injury
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26902
Abstract: To the Editor: Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/ myeloproliferative (MP) overlap neoplasm (MDS/MPN), characterized by sustained peripheral blood monocytosis (absolute monocyte count≥0.5 10/L, with monocytes comprising ≥10% of the white blood cell [WBC]… read more here.
Keywords: kidney; kidney injury; microscopy; range ... See more keywords
Recent Updates on Chronic Myelomonocytic Leukemia
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DOI: 10.1007/s11899-018-0475-5
Abstract: Purpose of ReviewThe goal of this review is to provide a practical and comprehensive update on changes in the classification of chronic myelomonocytic leukemia (CMML) and a summary of the most recent developments in our… read more here.
Keywords: recent updates; updates chronic; chronic myelomonocytic; cmml ... See more keywords
Chronic Myelomonocytic Leukemia: 2018 Update to Prognosis and Treatment
Sign Up to like & getrecommendations! Published in 2019 at "Current Hematologic Malignancy Reports"
DOI: 10.1007/s11899-019-00509-9
Abstract: Purpose of ReviewChronic myelomonocytic leukemia (CMML) is a rare and often aggressive myeloid malignancy. Historically, prognostic markers and therapeutic paradigms have been applied from myelodysplastic syndromes (MDS) or myeloproliferative neoplasms (MPNs). Interest has increased recently… read more here.
Keywords: prognosis; treatment; chronic myelomonocytic; cmml ... See more keywords
Allogeneic Transplant for CMML
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DOI: 10.1007/s11899-025-00754-1
Abstract: Chronic myelomonocytic leukemia (CMML) is a rare hematologic malignancy at the intersection of myelodysplastic (MDS) and myeloproliferative neoplasms, predominantly affecting older adults. Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative option, yet its application… read more here.
Keywords: post transplant; allogeneic transplant; transplant; malignancy ... See more keywords
ASXL1 frameshift mutations drive inferior outcomes in CMML without negative impact in MDS
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DOI: 10.1038/s41408-017-0004-0
Abstract: Next-generation sequencing (NGS) has revolutionized the diagnostic, prognostic and treatment paradigms in myeloid malignancies. Although somatic mutations can be identified in the majority of patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML), the… read more here.
Keywords: asxl1; impact; significance; mds ... See more keywords
Serotonin receptor type 1B constitutes a therapeutic target for MDS and CMML
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32306-4
Abstract: Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) are chronic myeloid clonal neoplasms. To date, the only potentially curative therapy for these disorders remains allogeneic hematopoietic progenitor cell transplantation (HCT), although patient eligibility is limited… read more here.
Keywords: mds cmml; target mds; cmml; therapeutic target ... See more keywords
Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.13999
Abstract: The steps in the progression from subclinical clonal haemopoiesis to acute myeloid leukaemia (AML) have not been defined, nor has its likelihood or latency. NPM1 mutations were not found to drive clonal haemopoiesis in haematologically… read more here.
Keywords: acquisition; myeloid leukaemia; acute myeloid; leukaemia ... See more keywords
Enhanced Survival of Chronic Myelomonocytic Leukemia-Dysplastic over Proliferative Subtype after Allogeneic Hematopoietic Cell Transplant: A Tertiary Center Experience and Literature Review
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DOI: 10.1159/000539880
Abstract: Abstract Introduction: CMML is a rare neoplasm with overlapping myelodysplastic and myeloproliferative features whose only potential cure is allogeneic hematopoietic cell transplantation (allo-HCT). Methods: This retrospective study examined 27 CMML patients with high-risk clinical features… read more here.
Keywords: hematopoietic cell; subtype; allogeneic hematopoietic; cmml ... See more keywords
Chronic myelomonocytic leukemia mimicking hematologic systemic lupus erythematosus
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DOI: 10.1177/0961203316657436
Abstract: The relationship between primary hematologic disease and rheumatologic manifestations is well known, especially acute lymphocytic leukemia, lymphomas, plasma cell dyscrasias and myelodysplastic syndrome (MDS). Currently, more has been described about autoimmune manifestations in chronic myelomonocytic… read more here.
Keywords: systemic lupus; chronic myelomonocytic; lupus; leukemia ... See more keywords
Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-06-724658
Abstract: Chronic myelomonocytic leukemia (CMML) is a hematological malignancy characterized by uncontrolled proliferation of dysplastic myelomonocytes and frequent progression to acute myeloid leukemia (AML). We identified mutations in the Cbl gene, which encodes a negative regulator… read more here.
Keywords: cbl; mice; cblq367p; leukemia ... See more keywords
CMML/JMML PDXs: as easy as 1, 2, NSG-SGM3.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-06-789123
Abstract: In this issue of Blood , Yoshimi et al describe a simple method to establish patient-derived xenografts (PDXs) of chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) with remarkable efficiency. These morphologically, immunophenotypically, and… read more here.
Keywords: pdxs easy; jmml; jmml pdxs; cmml jmml ... See more keywords