Spectrum of renal pathological findings in patients with chronic myelomonocytic leukemia and kidney injury
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DOI: 10.1002/ajh.26902
Abstract: To the Editor: Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/ myeloproliferative (MP) overlap neoplasm (MDS/MPN), characterized by sustained peripheral blood monocytosis (absolute monocyte count≥0.5 10/L, with monocytes comprising ≥10% of the white blood cell [WBC]… read more here.
Keywords: kidney; kidney injury; microscopy; range ... See more keywords
Recent Updates on Chronic Myelomonocytic Leukemia
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DOI: 10.1007/s11899-018-0475-5
Abstract: Purpose of ReviewThe goal of this review is to provide a practical and comprehensive update on changes in the classification of chronic myelomonocytic leukemia (CMML) and a summary of the most recent developments in our… read more here.
Keywords: recent updates; updates chronic; chronic myelomonocytic; cmml ... See more keywords
Chronic Myelomonocytic Leukemia: 2018 Update to Prognosis and Treatment
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DOI: 10.1007/s11899-019-00509-9
Abstract: Purpose of ReviewChronic myelomonocytic leukemia (CMML) is a rare and often aggressive myeloid malignancy. Historically, prognostic markers and therapeutic paradigms have been applied from myelodysplastic syndromes (MDS) or myeloproliferative neoplasms (MPNs). Interest has increased recently… read more here.
Keywords: prognosis; treatment; chronic myelomonocytic; cmml ... See more keywords
ASXL1 frameshift mutations drive inferior outcomes in CMML without negative impact in MDS
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DOI: 10.1038/s41408-017-0004-0
Abstract: Next-generation sequencing (NGS) has revolutionized the diagnostic, prognostic and treatment paradigms in myeloid malignancies. Although somatic mutations can be identified in the majority of patients with myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML), the… read more here.
Keywords: asxl1; impact; significance; mds ... See more keywords
Serotonin receptor type 1B constitutes a therapeutic target for MDS and CMML
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DOI: 10.1038/s41598-018-32306-4
Abstract: Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) are chronic myeloid clonal neoplasms. To date, the only potentially curative therapy for these disorders remains allogeneic hematopoietic progenitor cell transplantation (HCT), although patient eligibility is limited… read more here.
Keywords: mds cmml; target mds; cmml; therapeutic target ... See more keywords
Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution
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DOI: 10.1111/bjh.13999
Abstract: The steps in the progression from subclinical clonal haemopoiesis to acute myeloid leukaemia (AML) have not been defined, nor has its likelihood or latency. NPM1 mutations were not found to drive clonal haemopoiesis in haematologically… read more here.
Keywords: acquisition; myeloid leukaemia; acute myeloid; leukaemia ... See more keywords
Chronic myelomonocytic leukemia mimicking hematologic systemic lupus erythematosus
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DOI: 10.1177/0961203316657436
Abstract: The relationship between primary hematologic disease and rheumatologic manifestations is well known, especially acute lymphocytic leukemia, lymphomas, plasma cell dyscrasias and myelodysplastic syndrome (MDS). Currently, more has been described about autoimmune manifestations in chronic myelomonocytic… read more here.
Keywords: systemic lupus; chronic myelomonocytic; lupus; leukemia ... See more keywords
Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia.
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DOI: 10.1182/blood-2016-06-724658
Abstract: Chronic myelomonocytic leukemia (CMML) is a hematological malignancy characterized by uncontrolled proliferation of dysplastic myelomonocytes and frequent progression to acute myeloid leukemia (AML). We identified mutations in the Cbl gene, which encodes a negative regulator… read more here.
Keywords: cbl; mice; cblq367p; leukemia ... See more keywords
CMML/JMML PDXs: as easy as 1, 2, NSG-SGM3.
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DOI: 10.1182/blood-2017-06-789123
Abstract: In this issue of Blood , Yoshimi et al describe a simple method to establish patient-derived xenografts (PDXs) of chronic myelomonocytic leukemia (CMML) and juvenile myelomonocytic leukemia (JMML) with remarkable efficiency. These morphologically, immunophenotypically, and… read more here.
Keywords: pdxs easy; jmml; jmml pdxs; cmml jmml ... See more keywords
Geno-Clinical Model to Aid in the Diagnosis of Myelodysplastic Syndrome (MDS) Versus Chronic Myelomonocytic Leukemia (CMML)
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DOI: 10.1182/blood-2018-99-115180
Abstract: Background Myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) are mainly diagnosed based on morphological changes in the bone marrow. The diagnosis can be challenging in patients (pts) with pancytopenia with minimal dysplasia, and is… read more here.
Keywords: entity board; membership entity; mds; leukemia ... See more keywords
Prognostic Value of a New Clinically-Based Classification System in Patients with CMML Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Analysis of the EBMT Chronic Malignancies Working Party
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DOI: 10.1182/blood-2018-99-118490
Abstract: Introduction: A new 3-group clinical classification schema proposed by the International Consortium (Blood 2016,128:4320) and subsequently validated by the MDS Düsseldorf Registry (Leukemia Research 2017,55:S149) was shown to independently stratify Chronic Myelomonocytic Leukemia (CMML) patients… read more here.
Keywords: classification; analysis; hsct; stem cell ... See more keywords