Epigenetic therapy of myelodysplastic syndromes connects to cellular differentiation independently of endogenous retroelement derepression
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DOI: 10.1186/s13073-019-0707-x
Abstract: BackgroundMyelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) are characterised by abnormal epigenetic repression and differentiation of bone marrow haematopoietic stem cells (HSCs). Drugs that reverse epigenetic repression, such as 5-azacytidine (5-AZA), induce haematological improvement… read more here.
Keywords: treatment; cmml patients; patients aza; differentiation ... See more keywords
Clinical significance of CSF3R, SRSF2 and SETBP1 mutations in chronic neutrophilic leukemia and chronic myelomonocytic leukemia
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DOI: 10.18632/oncotarget.15355
Abstract: Chronic neutrophilic leukemia (CNL) and chronic myelomonocytic leukemia (CMML) are rare hematologic neoplasms. We performed CSF3R, SRSF2 and SETBP1 mutational analyses in 10 CNL and 56 CMML patients. In this sample cohort, 80% of CNL… read more here.
Keywords: cmml patients; setbp1; srsf2; csf3r ... See more keywords
Disappearance of slan-positive non-classical monocytes for diagnosis of chronic myelomonocytic leukemia with an associated inflammatory state
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DOI: 10.3324/haematol.2019.219782
Abstract: The diagnosis of chronic myelomonocytic leukemia (CMML) relies on both a persistent peripheral blood monocytosis (monocytes ≥1x10/L) and monocytes accounting for ≥10% of the white blood cell (WBC) differential count. We showed that a relative… read more here.
Keywords: figure; cmml patients; slan; blood ... See more keywords