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   Articles with "cmtm6" as a keyword



A CMTM6 Nanobody Overcomes EGFR‐TKI Resistance in Non‐Small Cell Lung Cancer

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202410945

Abstract: Aberrant EGFR signaling drives non‐small cell lung cancer (NSCLC) development, and despite the success of tyrosine kinase inhibitor (TKI) therapies in treating NSCLC, TKI resistance remains a major obstacle. Here, we report that the chemokine‐like… read more here.

Keywords: non small; tki resistance; cmtm6; cell ... See more keywords

Increased CMTM6 can predict the clinical response to PD-1 inhibitors in non-small cell lung cancer patients

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recommendations! Published in 2019 at "OncoImmunology"

DOI: 10.1080/2162402x.2019.1629261

Abstract: ABSTRACT CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) plays a crucial role in the stability of the programmed death-ligand 1 (PD-L1). However, there has been no previous study of CMTM6 in non-small cell lung cancer… read more here.

Keywords: expression; small cell; cancer; cmtm6 ... See more keywords

Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity

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recommendations! Published in 2022 at "Oncoimmunology"

DOI: 10.1080/2162402x.2021.2011673

Abstract: ABSTRACT Recent studies have revealed that chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) promotes tumor progression and modulates tumor immunity by regulating programmed death-ligand 1 stability; however, its intrinsic functions and regulatory mechanisms… read more here.

Keywords: cmtm6 promotes; cmtm6; dna damage; immunity ... See more keywords

Expression and Clinical Significance of CMTM6 in Hepatocellular Carcinoma.

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recommendations! Published in 2019 at "DNA and cell biology"

DOI: 10.1089/dna.2018.4513

Abstract: This study aimed to examine the expression level and clinical significance of chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) in paired hepatocellular carcinoma (HCC) and adjacent nontumor tissues. The expression of CMTM6 was… read more here.

Keywords: nontumor tissues; adjacent nontumor; hcc; cmtm6 expression ... See more keywords

High membrane expression of CMTM6 in hepatocellular carcinoma is associated with tumor recurrence

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recommendations! Published in 2021 at "Cancer Science"

DOI: 10.1111/cas.15004

Abstract: CKLF‐like MARVEL transmembrane domain–containing protein 6 (CMTM6) maintains membrane PD‐L1 expression by controlling its endosomal recycling. However, in patients with hepatocellular carcinoma (HCC), the correlation among CMTM6, B7 family ligands, and CD8‐positive cytotoxic T lymphocytes… read more here.

Keywords: hcc; recurrence; expression; cmtm6 ... See more keywords

Expression and Clinical Significance of CMTM6 and PD-L1 in Triple-Negative Breast Cancer

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recommendations! Published in 2022 at "BioMed Research International"

DOI: 10.1155/2022/8118909

Abstract: The CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) plays an extremely important role of the programed death receptor ligand-1 (PD-L1) protein. Our study is aimed at investigating the expression of CMTM6 and PD-L1 proteins in… read more here.

Keywords: cmtm6; triple negative; expression; breast cancer ... See more keywords

Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner

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recommendations! Published in 2022 at "Cancer Immunology Research"

DOI: 10.1158/2326-6066.cir-22-0439

Abstract: CKLF-like MARVEL transmembrane domain-containing 6 (CMTM6) has been identified as a regulator of membranal programmed death ligand 1 (PD-L1) stability and a factor associated with malignancy progression, but the effects and mechanisms of CMTM6 on… read more here.

Keywords: cytotoxicity; tumor host; cmtm6; suppression ... See more keywords
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CMTM6 drives cisplatin resistance by regulating Wnt signaling through the ENO-1/AKT/GSK3β axis

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recommendations! Published in 2021 at "JCI Insight"

DOI: 10.1172/jci.insight.143643

Abstract: Rewiring tumor cells to undergo drug-induced apoptosis is a promising way to overcome chemoresistance. Therefore, identifying causative factors for chemoresistance is of high importance. Unbiased global proteome profiling of sensitive, early, and late cisplatin-resistant oral… read more here.

Keywords: wnt signaling; cell carcinoma; squamous cell; cmtm6 ... See more keywords

CMTM6 drives glioblastoma progression by promoting M2 polarization and suppressing antigen presentation in microglia/macrophages

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recommendations! Published in 2025 at "European Journal of Medical Research"

DOI: 10.1186/s40001-025-03243-6

Abstract: Immune checkpoint blockade therapies, particularly targeting PD-1/PD-L1 axis, have shown limited efficacy in glioblastoma (GBM), primarily due to the profoundly immunosuppressive tumor microenvironment dominated by glioma-associated microglia and macrophages (GAMs). While CMTM6 is known to… read more here.

Keywords: cmtm6; tumor; expression; microglia macrophages ... See more keywords