Cytomegalovirus kinetics after hematopoietic cell transplantation reveal peak titers with differential impact on mortality, relapse and immune reconstitution
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26094
Abstract: Even in the era of PCR‐based monitoring, prophylaxis, and preemptive therapy, Cytomegalovirus (CMV) viremia remains a relevant cause of non‐relapse mortality (NRM) after allogeneic hematopoietic cell transplantation (HCT). However, studies using binary analysis (presence/absence of… read more here.
Keywords: cmv; reconstitution; relapse; peak ... See more keywords
Adoptive therapy with cytomegalovirus‐specific T cells for cytomegalovirus infection after haploidentical stem cell transplantation and factors affecting efficacy
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26535
Abstract: Adoptive therapy with cytomegalovirus (CMV)‐specific cytotoxic T lymphocytes (CMV‐CTLs) has emerged as an effective method for CMV infection. However, the efficacy reportedly ranges from 50% to 90%, and factors affecting anti‐CMV efficacy have not been… read more here.
Keywords: cmv ctl; adoptive therapy; infection; efficacy ... See more keywords
Hematopoietic stem cell donor vaccination with cytomegalovirus triplex augments frequencies of functional and durable cytomegalovirus‐specific T cells in the recipient: A novel strategy to limit antiviral prophylaxis
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26824
Abstract: To enhance protective cytomegalovirus (CMV)‐specific T cells in immunosuppressed recipients of an allogeneic hematopoietic cell transplant (HCT), we evaluated post‐HCT impact of vaccinating healthy HCT donors with Triplex. Triplex is a viral vectored recombinant vaccine… read more here.
Keywords: cell; cmv specific; specific cells; hct ... See more keywords
Early childhood outcomes of NICU graduates with cytomegalovirus infection in California.
Sign Up to like & getrecommendations! Published in 2023 at "Birth defects research"
DOI: 10.1002/bdr2.2203
Abstract: BACKGROUND To assess demographics and outcomes up to 3 years of age among children with cytomegalovirus (CMV) infection in California neonatal intensive care units (NICUs) during 2010-2021. METHODS The California Perinatal Quality Care Collaborative (CPQCC) collects… read more here.
Keywords: infection california; infection; cmv infection; birth ... See more keywords
Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cells
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DOI: 10.1002/biot.202200062
Abstract: Expression of recombinant genes in HEK293 cells is frequently utilized for production of recombinant proteins and viral vectors. These systems frequently employ the cytomegalovirus (CMV) promoter to drive recombinant gene transcription. However, the mechanistic basis… read more here.
Keywords: cmv; expression recombinant; recombinant genes; hek293 cells ... See more keywords
Chromatin Accessibility Plays an Important Epigenetic Role on Antibody Expression From CMV Promoter and DNA Elements Flanking the CHO TI Host Landing‐Pad
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology Journal"
DOI: 10.1002/biot.202400487
Abstract: Targeted integration (TI) Chinese hamster ovary (CHO) platforms are commonly used for protein expression. However, the impact of epigenetic modifications on protein expression in TI cell lines remains elusive since almost all the epigenetic studies… read more here.
Keywords: expression; chromatin accessibility; cmv; cho ... See more keywords
CMV drives the expansion of highly functional memory T cells expressing NK‐cell receptors in renal transplant recipients
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201747018
Abstract: Cytomegalovirus (CMV) is a common opportunistic infection encountered in renal transplant recipients (RTRs) and may be reactivated without symptoms at any time post‐transplant. We describe how active and latent CMV affect T‐cell subsets in RTRs… read more here.
Keywords: cmv; transplant; renal transplant; cell receptors ... See more keywords
Associations between early‐life and in utero infections and cytomegalovirus‐positive acute lymphoblastic leukemia in children
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34292
Abstract: Childhood infections and cytomegalovirus (CMV) are associated with pediatric acute lymphoblastic leukemia (ALL). CMV dysregulates the host immune system and alters the immune response to subsequent antigenic exposures. We suspect that this immune dysregulation contributes… read more here.
Keywords: cmv positive; lymphoblastic leukemia; acute lymphoblastic; cmv ... See more keywords
Transitioning cytomegalovirus viral load testing from a laboratory developed test to the cobas® CMV quantitative nucleic acid assay
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25189
Abstract: Commutability between human cytomegalovirus (CMV) viral load assays (VLA) is poor, despite the development of a WHO CMV International Standard (CMV IS). We evaluated a new CMV VLA, cobas® CMV, as compared to our current… read more here.
Keywords: viral load; cmv; laboratory developed; cobas cmv ... See more keywords
Cytomegalovirus Disease in Renal Allograft Recipients in the Current Immunosuppression Era
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70128
Abstract: The high prevalence of cytomegalovirus (CMV) after kidney transplantation, along with its significant morbidity, mortality, and financial burden, makes it a serious infectious complication. This retrospective observational study aimed to determine the incidence of CMV… read more here.
Keywords: disease; cmv; immunosuppression; cytomegalovirus ... See more keywords
Evaluation of the VIDAS Cytomegalovirus (CMV)‐IGRA for Assessing CMV‐Specific T‐Cell Responses in Immunocompetent and Immunosuppressed Individuals
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70355
Abstract: We compared the performance of the VIDAS Cytomegalovirus (CMV)‐Interferon‐gamma release assay (IGRA) with that of laboratory‐developed flow cytometry for intracellular cytokine staining (FC‐ICS) for the assessment of CMV‐specific interferon‐gamma (IFN‐γ)‐producing T‐cell responses (CMV‐CMI). A total… read more here.
Keywords: cmv igra; vidas cmv; cmv; cmv specific ... See more keywords