Cytomegalovirus kinetics after hematopoietic cell transplantation reveal peak titers with differential impact on mortality, relapse and immune reconstitution
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26094
Abstract: Even in the era of PCR‐based monitoring, prophylaxis, and preemptive therapy, Cytomegalovirus (CMV) viremia remains a relevant cause of non‐relapse mortality (NRM) after allogeneic hematopoietic cell transplantation (HCT). However, studies using binary analysis (presence/absence of… read more here.
Keywords: cmv; reconstitution; relapse; peak ... See more keywords
Adoptive therapy with cytomegalovirus‐specific T cells for cytomegalovirus infection after haploidentical stem cell transplantation and factors affecting efficacy
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26535
Abstract: Adoptive therapy with cytomegalovirus (CMV)‐specific cytotoxic T lymphocytes (CMV‐CTLs) has emerged as an effective method for CMV infection. However, the efficacy reportedly ranges from 50% to 90%, and factors affecting anti‐CMV efficacy have not been… read more here.
Keywords: cmv ctl; adoptive therapy; infection; efficacy ... See more keywords
Hematopoietic stem cell donor vaccination with cytomegalovirus triplex augments frequencies of functional and durable cytomegalovirus‐specific T cells in the recipient: A novel strategy to limit antiviral prophylaxis
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26824
Abstract: To enhance protective cytomegalovirus (CMV)‐specific T cells in immunosuppressed recipients of an allogeneic hematopoietic cell transplant (HCT), we evaluated post‐HCT impact of vaccinating healthy HCT donors with Triplex. Triplex is a viral vectored recombinant vaccine… read more here.
Keywords: cell; cmv specific; specific cells; hct ... See more keywords
Early childhood outcomes of NICU graduates with cytomegalovirus infection in California.
Sign Up to like & getrecommendations! Published in 2023 at "Birth defects research"
DOI: 10.1002/bdr2.2203
Abstract: BACKGROUND To assess demographics and outcomes up to 3 years of age among children with cytomegalovirus (CMV) infection in California neonatal intensive care units (NICUs) during 2010-2021. METHODS The California Perinatal Quality Care Collaborative (CPQCC) collects… read more here.
Keywords: infection california; infection; cmv infection; birth ... See more keywords
Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cells
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DOI: 10.1002/biot.202200062
Abstract: Expression of recombinant genes in HEK293 cells is frequently utilized for production of recombinant proteins and viral vectors. These systems frequently employ the cytomegalovirus (CMV) promoter to drive recombinant gene transcription. However, the mechanistic basis… read more here.
Keywords: cmv; expression recombinant; recombinant genes; hek293 cells ... See more keywords
CMV drives the expansion of highly functional memory T cells expressing NK‐cell receptors in renal transplant recipients
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DOI: 10.1002/eji.201747018
Abstract: Cytomegalovirus (CMV) is a common opportunistic infection encountered in renal transplant recipients (RTRs) and may be reactivated without symptoms at any time post‐transplant. We describe how active and latent CMV affect T‐cell subsets in RTRs… read more here.
Keywords: cmv; transplant; renal transplant; cell receptors ... See more keywords
Associations between early‐life and in utero infections and cytomegalovirus‐positive acute lymphoblastic leukemia in children
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DOI: 10.1002/ijc.34292
Abstract: Childhood infections and cytomegalovirus (CMV) are associated with pediatric acute lymphoblastic leukemia (ALL). CMV dysregulates the host immune system and alters the immune response to subsequent antigenic exposures. We suspect that this immune dysregulation contributes… read more here.
Keywords: cmv positive; lymphoblastic leukemia; acute lymphoblastic; cmv ... See more keywords
Transitioning cytomegalovirus viral load testing from a laboratory developed test to the cobas® CMV quantitative nucleic acid assay
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25189
Abstract: Commutability between human cytomegalovirus (CMV) viral load assays (VLA) is poor, despite the development of a WHO CMV International Standard (CMV IS). We evaluated a new CMV VLA, cobas® CMV, as compared to our current… read more here.
Keywords: viral load; cmv; laboratory developed; cobas cmv ... See more keywords
Glial fibrillary acidic protein promoter determines transgene expression in satellite glial cells following intraganglionic adeno‐associated virus delivery in adult rats
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DOI: 10.1002/jnr.24183
Abstract: Recombinant adeno‐associated viral (AAV)‐mediated therapeutic gene transfer to dorsal root ganglia (DRG) is an effective and safe tool for treating chronic pain. However, AAV with various constitutively active promoters leads to transgene expression predominantly to… read more here.
Keywords: cmv; expression; promoter; transduction ... See more keywords
Coronavirus disease 2019 as a syndemic
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DOI: 10.1002/rmv.2212
Abstract: It seems that human nature has not changed much over the past third of a millennium. Contemporary newspapers are replete with photographs of people ignoring advice about social distancing. Many, but not all, of these… read more here.
Keywords: cmv; disease 2019; disease; sars cov ... See more keywords
Indirect effects of cytomegalovirus infection: Implications for vaccine development
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DOI: 10.1002/rmv.2405
Abstract: Development of a cytomegalovirus (CMV) vaccine is a high priority due to its significant global impact—contributing to mortality in immunosuppressed individuals, neurodevelopmental delay in infected neonates and non‐genetic sensorineural hearing loss. The impact of CMV… read more here.
Keywords: development; cytomegalovirus infection; impact; effects cytomegalovirus ... See more keywords