Hematopoietic stem cell donor vaccination with cytomegalovirus triplex augments frequencies of functional and durable cytomegalovirus‐specific T cells in the recipient: A novel strategy to limit antiviral prophylaxis
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26824
Abstract: To enhance protective cytomegalovirus (CMV)‐specific T cells in immunosuppressed recipients of an allogeneic hematopoietic cell transplant (HCT), we evaluated post‐HCT impact of vaccinating healthy HCT donors with Triplex. Triplex is a viral vectored recombinant vaccine… read more here.
Keywords: cell; cmv specific; specific cells; hct ... See more keywords
Generation of high-affinity CMV-specific T cells for adoptive immunotherapy using IL-2, IL-15, and IL-21.
Sign Up to like & getrecommendations! Published in 2020 at "Clinical immunology"
DOI: 10.1016/j.clim.2020.108456
Abstract: Cytomegalovirus (CMV) infection remains a life-threatening condition in individuals with a suppressed immune system. CMV may also represent a clinically relevant target for immune responses in CMV-positive malignancies. We established a protocol to expand CMV-specific… read more here.
Keywords: affinity cmv; cmv; high affinity; specific cells ... See more keywords
CMV seronegative donors: Effect on clinical severity of CMV infection and reconstitution of CMV-specific immunity.
Sign Up to like & getrecommendations! Published in 2018 at "Transplant immunology"
DOI: 10.1016/j.trim.2018.04.003
Abstract: BACKGROUND Cytomegalovirus (CMV)-specific T-cells are crucial to prevent CMV disease. CMV seropositive recipients transplanted with stem cells from a CMV seronegative allogeneic donor (R+D-) may be at risk for CMV disease due to absence of… read more here.
Keywords: cmv; cmv disease; cmv seronegative; cmv specific ... See more keywords
CMV specific T cell immunity predicts early viremia after liver transplantation.
Sign Up to like & getrecommendations! Published in 2018 at "Transplant immunology"
DOI: 10.1016/j.trim.2018.09.004
Abstract: BACKGROUND Cytomegalovirus (CMV) infection is one of the most important factors affecting liver transplant with direct and indirect effects. However, CMV disease after transplant remains poorly predicted. OBJECTIVE In this study, preoperative CMV-specific cell-mediated immunity… read more here.
Keywords: cmv; immunity; specific cell; liver ... See more keywords
CMV specific T cell immune response in hepatitis C negative kidney transplant recipients receiving transplant from hepatitis C viremic donors and hepatitis C aviremic donors
Sign Up to like & getrecommendations! Published in 2022 at "Renal Failure"
DOI: 10.1080/0886022x.2022.2072744
Abstract: Abstract Kidney transplants (KT) from hepatitis C (HCV) viremic donors to HCV negative recipients has shown promising renal outcomes, however, high incidence of cytomegalovirus (CMV) viremia were reported. We performed a prospective cohort study of… read more here.
Keywords: cell; immune response; cmv specific; cell immune ... See more keywords
Donor CMV-specific cytotoxic T lymphocytes successfully treated drug-resistant cytomegalovirus encephalitis after allogeneic hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2020 at "Hematology"
DOI: 10.1080/16078454.2019.1710945
Abstract: ABSTRACT Background: Cytomegalovirus (CMV) infection of the central nervous system (CNS) is a rare but life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Cases presentation: Two patients with drug-resistant CMV encephalitis after allo-HSCT were… read more here.
Keywords: cmv; donor cmv; cmv specific; transplantation ... See more keywords
Large-scale manufacturing and characterization of CMV-CD19CAR T cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003461
Abstract: Background Adoptive transfer of CD19-specific chimeric antigen receptor (CD19CAR) T cells can induce dramatic disease regression in patients with B cell malignancies. CD19CAR T cell therapy may be limited by insufficient engraftment and persistence, resulting… read more here.
Keywords: cmv specific; specific cells; cmv cd19car; cd19car ... See more keywords
MVA vaccine encoding CMV antigens safely induces durable expansion of CMV-specific T cells in healthy adults.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-07-729756
Abstract: Attenuated poxvirus modified vaccinia Ankara (MVA) is a useful viral-based vaccine for clinical investigation, because of its excellent safety profile and property of inducing potent immune responses against recombinant (r) antigens. We developed Triplex by… read more here.
Keywords: healthy adults; cmv; cmv antigens; specific cells ... See more keywords
CMV-Specific T Cells Restricted By Shared and Donor, but Not By Host HLA Molecules Reconstitute in the First 180 Days after Allogeneic HSCT and Protect from CMV Reactivation: Results of a Prospective Observational Study
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-129779
Abstract: Introduction: Cytomegalovirus (CMV) reactivation and disease are important risk factors after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and strongly affect morbidity and mortality after transplant. CMV-specific T cell reconstitution controls CMV reactivation and protects against… read more here.
Keywords: cmv; hla; cmv specific; host ... See more keywords
Clinical experience with a novel assay measuring cytomegalovirus (CMV)-specific CD4+ and CD8+ T-cell immunity by flow cytometry and intracellular cytokine staining to predict clinically significant CMV events
Sign Up to like & getrecommendations! Published in 2020 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-020-4787-4
Abstract: Background Cytomegalovirus (CMV) infection is one of the most common opportunistic infections following organ transplantation, despite administration of CMV prophylaxis. CMV-specific T-cell immunity (TCI) has been associated with reduced rates of CMV infection. We describe… read more here.
Keywords: cmv; cmv specific; significant cmv; specific cd4 ... See more keywords
Cytomegalovirus-specific T cells restricted for shared and donor human leukocyte antigens differentially impact on cytomegalovirus reactivation risk after allogeneic hematopoietic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.280685
Abstract: After allogeneic hematopoietic stem cell transplantation (HSCT), the emergence of circulating cytomegalovirus (CMV)-specific T cells correlates with protection from CMV reactivation, an important risk factor for non-relapse mortality. However, functional assays measuring CMV-specific cells are… read more here.
Keywords: cmv specific; specific cells; reactivation; risk ... See more keywords