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   Articles with "cmv specific" as a keyword



Hematopoietic stem cell donor vaccination with cytomegalovirus triplex augments frequencies of functional and durable cytomegalovirus‐specific T cells in the recipient: A novel strategy to limit antiviral prophylaxis

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recommendations! Published in 2023 at "American Journal of Hematology"

DOI: 10.1002/ajh.26824

Abstract: To enhance protective cytomegalovirus (CMV)‐specific T cells in immunosuppressed recipients of an allogeneic hematopoietic cell transplant (HCT), we evaluated post‐HCT impact of vaccinating healthy HCT donors with Triplex. Triplex is a viral vectored recombinant vaccine… read more here.

Keywords: cell; cmv specific; specific cells; hct ... See more keywords

Evaluation of the VIDAS Cytomegalovirus (CMV)‐IGRA for Assessing CMV‐Specific T‐Cell Responses in Immunocompetent and Immunosuppressed Individuals

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recommendations! Published in 2025 at "Journal of Medical Virology"

DOI: 10.1002/jmv.70355

Abstract: We compared the performance of the VIDAS Cytomegalovirus (CMV)‐Interferon‐gamma release assay (IGRA) with that of laboratory‐developed flow cytometry for intracellular cytokine staining (FC‐ICS) for the assessment of CMV‐specific interferon‐gamma (IFN‐γ)‐producing T‐cell responses (CMV‐CMI). A total… read more here.

Keywords: cmv igra; vidas cmv; cmv; cmv specific ... See more keywords

Generation of high-affinity CMV-specific T cells for adoptive immunotherapy using IL-2, IL-15, and IL-21.

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recommendations! Published in 2020 at "Clinical immunology"

DOI: 10.1016/j.clim.2020.108456

Abstract: Cytomegalovirus (CMV) infection remains a life-threatening condition in individuals with a suppressed immune system. CMV may also represent a clinically relevant target for immune responses in CMV-positive malignancies. We established a protocol to expand CMV-specific… read more here.

Keywords: affinity cmv; cmv; high affinity; specific cells ... See more keywords

CMV seronegative donors: Effect on clinical severity of CMV infection and reconstitution of CMV-specific immunity.

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recommendations! Published in 2018 at "Transplant immunology"

DOI: 10.1016/j.trim.2018.04.003

Abstract: BACKGROUND Cytomegalovirus (CMV)-specific T-cells are crucial to prevent CMV disease. CMV seropositive recipients transplanted with stem cells from a CMV seronegative allogeneic donor (R+D-) may be at risk for CMV disease due to absence of… read more here.

Keywords: cmv; cmv disease; cmv seronegative; cmv specific ... See more keywords

CMV specific T cell immunity predicts early viremia after liver transplantation.

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recommendations! Published in 2018 at "Transplant immunology"

DOI: 10.1016/j.trim.2018.09.004

Abstract: BACKGROUND Cytomegalovirus (CMV) infection is one of the most important factors affecting liver transplant with direct and indirect effects. However, CMV disease after transplant remains poorly predicted. OBJECTIVE In this study, preoperative CMV-specific cell-mediated immunity… read more here.

Keywords: cmv; immunity; specific cell; liver ... See more keywords

CMV specific T cell immune response in hepatitis C negative kidney transplant recipients receiving transplant from hepatitis C viremic donors and hepatitis C aviremic donors

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recommendations! Published in 2022 at "Renal Failure"

DOI: 10.1080/0886022x.2022.2072744

Abstract: Abstract Kidney transplants (KT) from hepatitis C (HCV) viremic donors to HCV negative recipients has shown promising renal outcomes, however, high incidence of cytomegalovirus (CMV) viremia were reported. We performed a prospective cohort study of… read more here.

Keywords: cell; immune response; cmv specific; cell immune ... See more keywords
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Donor CMV-specific cytotoxic T lymphocytes successfully treated drug-resistant cytomegalovirus encephalitis after allogeneic hematopoietic stem cell transplantation

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recommendations! Published in 2020 at "Hematology"

DOI: 10.1080/16078454.2019.1710945

Abstract: ABSTRACT Background: Cytomegalovirus (CMV) infection of the central nervous system (CNS) is a rare but life-threatening complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Cases presentation: Two patients with drug-resistant CMV encephalitis after allo-HSCT were… read more here.

Keywords: cmv; donor cmv; cmv specific; transplantation ... See more keywords

Persistence of CMV-specific anti-HIV CAR T cells after adoptive immunotherapy

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recommendations! Published in 2025 at "Journal of Virology"

DOI: 10.1128/jvi.01933-24

Abstract: ABSTRACT The success of chimeric antigen receptor (CAR)-T cell (Tc) immunotherapy in refractory B-cell acute lymphoblastic leukemia (B-ALL) suggests adaptation of this strategy toward HIV. Because cytomegalovirus (CMV) vaccine vectors generated Tc responses that controlled… read more here.

Keywords: car2; replication; hiv; cmv ... See more keywords

Large-scale manufacturing and characterization of CMV-CD19CAR T cells

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recommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"

DOI: 10.1136/jitc-2021-003461

Abstract: Background Adoptive transfer of CD19-specific chimeric antigen receptor (CD19CAR) T cells can induce dramatic disease regression in patients with B cell malignancies. CD19CAR T cell therapy may be limited by insufficient engraftment and persistence, resulting… read more here.

Keywords: cmv specific; specific cells; cmv cd19car; cd19car ... See more keywords

MVA vaccine encoding CMV antigens safely induces durable expansion of CMV-specific T cells in healthy adults.

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood-2016-07-729756

Abstract: Attenuated poxvirus modified vaccinia Ankara (MVA) is a useful viral-based vaccine for clinical investigation, because of its excellent safety profile and property of inducing potent immune responses against recombinant (r) antigens. We developed Triplex by… read more here.

Keywords: healthy adults; cmv; cmv antigens; specific cells ... See more keywords

CMV-Specific T Cells Restricted By Shared and Donor, but Not By Host HLA Molecules Reconstitute in the First 180 Days after Allogeneic HSCT and Protect from CMV Reactivation: Results of a Prospective Observational Study

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-129779

Abstract: Introduction: Cytomegalovirus (CMV) reactivation and disease are important risk factors after allogeneic hematopoietic stem cell transplantation (allo-HSCT), and strongly affect morbidity and mortality after transplant. CMV-specific T cell reconstitution controls CMV reactivation and protects against… read more here.

Keywords: cmv; hla; cmv specific; host ... See more keywords