Cyclic nucleotide selectivity of protein kinase G isozymes
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DOI: 10.1002/pro.4008
Abstract: The intrinsic activity of the C‐terminal catalytic (C) domain of cyclic guanosine monophosphate (cGMP)‐dependent protein kinases (PKG) is inhibited by interactions with the N‐terminal regulatory (R) domain. Selective binding of cGMP to cyclic nucleotide binding… read more here.
Keywords: cyclic nucleotide; selectivity; cnb domains; cgmp ... See more keywords
Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma
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DOI: 10.1038/s41467-019-09338-z
Abstract: Protein kinase A (PKA), the main effector of cAMP in eukaryotes, is a paradigm for the mechanisms of ligand-dependent and allosteric regulation in signalling. Here we report the orthologous but cAMP-independent PKA of the protozoan… read more here.
Keywords: camp; cnb domains; pka; protein kinase ... See more keywords