Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis.
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DOI: 10.1016/j.kint.2021.06.030
Abstract: Adverse effects of calcineurin inhibitors (CNI), such as hypertension, hyperkalemia, acidosis, hypomagnesemia and hypercalciuria, have been linked to dysfunction of the distal convoluted tubule (DCT). To test this, we generated a mouse model with an… read more here.
Keywords: acidosis; calcineurin; distal convoluted; cnb1 mice ... See more keywords