Ineffectiveness of high‐dose methotrexate for prevention of CNS relapse in diffuse large B‐cell lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26181
Abstract: Central nervous system (CNS) relapse affects 5% of diffuse large B‐cell lymphoma (DLBCL) patients and portends a poor prognosis. Prophylactic intravenous high‐dose methotrexate (HD‐MTX) is frequently employed to reduce this risk, but there is limited… read more here.
Keywords: lymphoma; risk; cns relapse; cns ... See more keywords
Diffuse large B-cell lymphoma at risk of secondary CNS involvement: The inefficacy of intravenous high-dose methotrexate CNS prophylaxis and the importance of baseline cerebrospinal fluid analysis.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of hematology"
DOI: 10.1002/ajh.26953
Abstract: High-dose intravenous methotrexate (HD-MTX) CNS prophylaxis in high-risk diffuse large B cell lymphoma (DLBCL) remains controversial. We describe real-world CNS relapse incidence following baseline cerebrospinal fluid (CSF) analysis to exclude asymptomatic leptomeningeal involvement in newly… read more here.
Keywords: involvement; cns; risk; analysis ... See more keywords
Microglial tissue surveillance: The never-resting gardener in the developing and adult CNS.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250232
Abstract: Immunosurveillance by microglia is a dynamic process in the central nervous system (CNS) with versatile functions to maintain tissue homeostasis and provide immune defense. A tightly controlled microglia network throughout the CNS parenchyma facilitates efficient… read more here.
Keywords: tissue surveillance; surveillance never; cns; microglial tissue ... See more keywords
Array‐based profiling of the lymphoma cell DNA methylome does not unequivocally distinguish primary lymphomas of the central nervous system from non‐CNS diffuse large B‐cell lymphomas
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22687
Abstract: Primary lymphomas of the central nervous system (PCNSL) are diffuse large B‐cell lymphomas (DLBCLs) confined to the central nervous system (CNS). We here performed array‐based DNA methylation analyses of 26 PCNSL and 78 DLBCL and… read more here.
Keywords: nervous system; central nervous; cns; non cns ... See more keywords
Targeting microglia attenuates neuroinflammation‐related neural damage in mice carrying human PLP1 mutations
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23539
Abstract: Genetically caused neurological disorders of the central nervous system (CNS) usually result in poor or even fatal clinical outcome and few or no causative treatments are available. Often, these disorders are associated with disease‐amplifying neuroinflammation,… read more here.
Keywords: plp1; related neural; cns; neuroinflammation related ... See more keywords
Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies
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DOI: 10.1002/ptr.7825
Abstract: Rosmarinic acid (RA) is a natural phenolic compound present in culinary herbs of the Boraginaceae, Lamiaceae/Labiatae, and Nepetoideae families. While the medicinal applications of these plants have been known for ages, RA has only been… read more here.
Keywords: rosmarinic acid; molecular mechanisms; cns; offerings rosmarinic ... See more keywords
Special Annual Issue on CNS Infections
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DOI: 10.1007/s00381-018-3916-5
Abstract: Dear Editor: The brain and the spinal cord are truly well protected from infections by the skull and the bony spine and are surrounded by layers of meninges which form a strongmechanical barrier. This defense… read more here.
Keywords: article; annual issue; cns; special annual ... See more keywords
The oncogenic fusion landscape in pediatric CNS neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "Acta Neuropathologica"
DOI: 10.1007/s00401-022-02405-8
Abstract: Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-related deaths in children. Recent developments in molecular analyses have greatly contributed to a more accurate diagnosis and risk stratification of CNS… read more here.
Keywords: fusion; cns; pediatric cns; cns neoplasms ... See more keywords
CSF interleukin 6 is a useful marker to distinguish pseudotumoral CNS inflammatory diseases from primary CNS lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurology"
DOI: 10.1007/s00415-021-10453-5
Abstract: Interleukin 6 (IL-6) is a pleomorphic cytokine that can be found in the cerebrospinal fluid (CSF) in a wide spectrum of inflammatory pathologies of the central nervous system (CNS). Our aim was to characterize the… read more here.
Keywords: cns lymphoma; cns; inflammatory diseases; csf ... See more keywords
Food-derived coagulase-negative Staphylococcus as starter cultures for fermented foods
Sign Up to like & getrecommendations! Published in 2020 at "Food Science and Biotechnology"
DOI: 10.1007/s10068-020-00789-5
Abstract: Food safety is of significant concern to consumers and is a major issue for the food industry. As such, the industry is aware of the importance of safety assessments of starters used in the production… read more here.
Keywords: food derived; fermented foods; safety; cns ... See more keywords
The neurological manifestations of COVID-19: a review article
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DOI: 10.1007/s10072-020-04486-3
Abstract: Results Various neurological manifestations have been reported in the literature associated with COVID-19, which in the current study are classified into Central Nervous System (CNS) related manifestations including headache, dizziness, impaired consciousness, acute cerebrovascular disease,… read more here.
Keywords: review article; cns; manifestations covid; covid review ... See more keywords