Targeting CNS Metastases in Non-Small Cell Lung Cancer With Evolving Approaches Using Molecular Markers: A Review.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2024.5218
Abstract: Importance Central nervous system (CNS) metastases presenting as either brain parenchymal metastases or leptomeningeal metastases are diagnosed in up to 50% of patients with advanced non-small cell lung cancer during their disease course. While historically… read more here.
Keywords: non small; therapy; cell lung; small cell ... See more keywords
Ineffectiveness of high‐dose methotrexate for prevention of CNS relapse in diffuse large B‐cell lymphoma
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26181
Abstract: Central nervous system (CNS) relapse affects 5% of diffuse large B‐cell lymphoma (DLBCL) patients and portends a poor prognosis. Prophylactic intravenous high‐dose methotrexate (HD‐MTX) is frequently employed to reduce this risk, but there is limited… read more here.
Keywords: lymphoma; risk; cns relapse; cns ... See more keywords
Diffuse large B-cell lymphoma at risk of secondary CNS involvement: The inefficacy of intravenous high-dose methotrexate CNS prophylaxis and the importance of baseline cerebrospinal fluid analysis.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of hematology"
DOI: 10.1002/ajh.26953
Abstract: High-dose intravenous methotrexate (HD-MTX) CNS prophylaxis in high-risk diffuse large B cell lymphoma (DLBCL) remains controversial. We describe real-world CNS relapse incidence following baseline cerebrospinal fluid (CSF) analysis to exclude asymptomatic leptomeningeal involvement in newly… read more here.
Keywords: involvement; cns; risk; analysis ... See more keywords
Central nervous system multiple myeloma: A real‐world multi‐institutional study of the Greek Myeloma Study Group
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Hematology"
DOI: 10.1002/ajh.27425
Abstract: Central nervous system (CNS) involvement is a rare and aggressive complication of multiple myeloma (MM). We identified 54/4352 MM patients (1.2%), who developed CNS‐MM between 2000 and 2022. A matched‐control group of MM patients without CNS‐MM… read more here.
Keywords: central nervous; multiple myeloma; nervous system; cns ... See more keywords
Determinants of firms' initiative and inertia in pursuing climate neutrality strategies—Theoretical explanations and empirical evidence
Sign Up to like & getrecommendations! Published in 2024 at "Business Strategy and the Environment"
DOI: 10.1002/bse.3698
Abstract: In view of global warming and growing demands that economies, industries, and firms should be climate‐neutral by mid‐century, various sources complain that firms are still hesitant to implement a corresponding climate neutrality strategy (CNS). To… read more here.
Keywords: inertia; climate; empirical evidence; cns ... See more keywords
Balancing CIK Cell Cancer Immunotherapy and PPAR Ligands: One Potential Therapeutic Application for CNS Malignancies
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70497
Abstract: Cytokine‐induced killer (CIK) cell therapy has proven successful in clinical trials regarding glioblastoma. Equally important are the hints suggesting peroxisome proliferator‐activated receptors (PPARs) ligands being co‐expressed in the central nervous system (CNS). This provides a… read more here.
Keywords: balancing cik; cancer; cns; cik ... See more keywords
Microglial tissue surveillance: The never-resting gardener in the developing and adult CNS.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250232
Abstract: Immunosurveillance by microglia is a dynamic process in the central nervous system (CNS) with versatile functions to maintain tissue homeostasis and provide immune defense. A tightly controlled microglia network throughout the CNS parenchyma facilitates efficient… read more here.
Keywords: tissue surveillance; surveillance never; cns; microglial tissue ... See more keywords
Array‐based profiling of the lymphoma cell DNA methylome does not unequivocally distinguish primary lymphomas of the central nervous system from non‐CNS diffuse large B‐cell lymphomas
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22687
Abstract: Primary lymphomas of the central nervous system (PCNSL) are diffuse large B‐cell lymphomas (DLBCLs) confined to the central nervous system (CNS). We here performed array‐based DNA methylation analyses of 26 PCNSL and 78 DLBCL and… read more here.
Keywords: nervous system; central nervous; cns; non cns ... See more keywords
Targeting microglia attenuates neuroinflammation‐related neural damage in mice carrying human PLP1 mutations
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23539
Abstract: Genetically caused neurological disorders of the central nervous system (CNS) usually result in poor or even fatal clinical outcome and few or no causative treatments are available. Often, these disorders are associated with disease‐amplifying neuroinflammation,… read more here.
Keywords: plp1; related neural; cns; neuroinflammation related ... See more keywords
Enhancement of the Functional Properties of Vinyl Ester Composites Using Alkali‐Treated Cocos nucifera Shell Biochar for Sustainable Applications
Sign Up to like & getrecommendations! Published in 2025 at "Polymer Composites"
DOI: 10.1002/pc.70233
Abstract: The objective of this study is to enhance the mechanical, thermal, dielectric, and functional characteristics of vinyl ester composites by adding environmentally friendly alkali‐treated Cocos nucifera shell (CNS) biochar for high‐performance, sustainable material applications. Six… read more here.
Keywords: ester composites; alkali treated; vinyl ester; biochar ... See more keywords
Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies
Sign Up to like & getrecommendations! Published in 2023 at "Phytotherapy Research"
DOI: 10.1002/ptr.7825
Abstract: Rosmarinic acid (RA) is a natural phenolic compound present in culinary herbs of the Boraginaceae, Lamiaceae/Labiatae, and Nepetoideae families. While the medicinal applications of these plants have been known for ages, RA has only been… read more here.
Keywords: rosmarinic acid; molecular mechanisms; cns; offerings rosmarinic ... See more keywords