Identification of Novel Quinolone and Quinazoline Alkaloids as Phosphodiesterase 10A Inhibitors for Parkinson’s Disease through a Computational Approach
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DOI: 10.1021/acsomega.3c10351
Abstract: Phosphodiesterases (PDEs) are vital in signal transduction, specifically by hydrolyzing cAMP and cGMP. Within the PDE family, PDE10A is notable for its prominence in the striatum and its regulatory function over neurotransmitters in medium-spiny neurons.… read more here.
Keywords: cns active; quinazoline; pde10a; quinolone ... See more keywords
Change in central nervous system-active medication use following fall-related injury in older adults.
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DOI: 10.1111/jgs.17508
Abstract: BACKGROUND Central nervous system (CNS)-active medication use is an important modifiable risk factor for falls in older adults. A fall-related injury should prompt providers to evaluate and reduce CNS-active medications to prevent recurrent falls. We… read more here.
Keywords: cns active; fall related; use; related injury ... See more keywords
Prevalence of central nervous system-active polypharmacy in a cohort of older adults in Argentina
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DOI: 10.1192/bjo.2024.798
Abstract: Background Central nervous system (CNS)-active polypharmacy is frequent and potentially harmful in older patients. Data on its burden outside the USA and European countries remain limited. Aims To estimate the period prevalence of and factors… read more here.
Keywords: central nervous; nervous system; polypharmacy; cns active ... See more keywords
Design, Synthesis, and Pharmacology of New Triazole-Containing Quinolinones as CNS Active Agents
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DOI: 10.3390/molecules28041987
Abstract: Epilepsy and major depressive disorder are the two of the most common central nervous system (CNS) diseases. Clinicians and patients call for new antidepressants, antiseizure medicines, and in particular drugs for depression and epilepsy comorbidities.… read more here.
Keywords: new triazole; active agents; pharmacology; immobility time ... See more keywords