Surface-engineered multimodal magnetic nanoparticles to manage CNS diseases.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.01.006
Abstract: Advanced central nervous system (CNS) therapies exhibited high efficacy but complete treatment of CNS diseases remains challenging owing to limited delivery of therapeutic agents to the brain. Multifunctional magnetic nanoparticles are investigated not only for… read more here.
Keywords: cns diseases; magnetic nanoparticles; manage cns; surface engineered ... See more keywords
Application and advantages of zebrafish model in the study of neurovascular unit.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174483
Abstract: The concept of "Neurovascular Unit" (NVU) was put forward, so that the research goal of Central Nervous System (CNS) diseases gradually transitioned from a single neuron to the structural and functional integrity of the NVU.… read more here.
Keywords: model; neurovascular unit; cns diseases; zebrafish model ... See more keywords
Phosphodiesterase 7(PDE7): A unique drug target for central nervous system diseases
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108694
Abstract: Phosphodiesterase 7 (PDE7), one of the 11 phosphodiesterase (PDE) families, specifically hydrolyzes cyclic 3', 5'-adenosine monophosphate (cAMP). PDE7 is involved in many important functional processes in physiology and pathology by regulating intracellular cAMP signaling. Studies… read more here.
Keywords: pde7; cns diseases; nervous system; central nervous ... See more keywords
Excessive apoptosis and ROS induced by ethionine affect neural cell viability and differentiation.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmaa093
Abstract: The central nervous system (CNS) diseases are still a major cause of morbidity and mortality throughout the world, which imposes heavy burden on the development of society. Ethionine is a non-proteinogenic amino acid having similar… read more here.
Keywords: cell viability; cns diseases; apoptosis; differentiation ... See more keywords
Galectin-3 in Microglia-Mediated Neuroinflammation: Implications for Central Nervous System Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Current Neuropharmacology"
DOI: 10.2174/1570159x20666220201094547
Abstract: Microglial activation is one of the common hallmarks shared by various central nervous system (CNS) diseases. Based on surrounding circumstances, activated microglia play either detrimental or neuroprotective effects. Galectin-3 (Gal-3), a group of β-galactoside-binding proteins,… read more here.
Keywords: mediated neuroinflammation; cns diseases; neuroinflammation; central nervous ... See more keywords
Challenges in Differentiating Pediatric Autoimmune CNS Diseases with Similar Clinical and Imaging Phenotypes
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Neuroradiology"
DOI: 10.3174/ajnr.a6196
Abstract: We would like to commend Bulut et al[1][1] for their investigation of brain MR imaging findings that could potentially be useful in discriminating pediatric-onset neuromyelitis optica spectrum disorder (NMOSD) from acute disseminated encephalomyelitis (ADEM). These… read more here.
Keywords: diseases similar; autoimmune cns; differentiating pediatric; challenges differentiating ... See more keywords
Research progress on acupuncture treatment in central nervous system diseases based on NLRP3 inflammasome in animal models
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1118508
Abstract: Central nervous system (CNS) disorders exhibit complex neurophysiological and pathological mechanisms, which seriously affect the quality of life in patients. Acupuncture, widely accepted as complementary and alternative medicine, has been proven to exert significant therapeutic… read more here.
Keywords: system; acupuncture; cns diseases; central nervous ... See more keywords
Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases
Sign Up to like & getrecommendations! Published in 2019 at "Antibodies"
DOI: 10.3390/antib8020027
Abstract: Antibodies have become one of the most successful therapeutics for a number of oncology and inflammatory diseases. So far, central nervous system (CNS) indications have missed out on the antibody revolution, while they remain ‘hidden’… read more here.
Keywords: cns diseases; antibody; single domain; domain antibodies ... See more keywords
Development of PPARγ Agonists for the Treatment of Neuroinflammatory and Neurodegenerative Diseases: Leriglitazone as a Promising Candidate
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043201
Abstract: Increasing evidence suggests that the peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, plays an important role in physiological processes in the central nervous system (CNS) and is involved in cellular… read more here.
Keywords: development ppar; ppar; cns diseases; ppar agonists ... See more keywords
Think Big, Start Small: How Nanomedicine Could Alleviate the Burden of Rare CNS Diseases
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14020109
Abstract: The complexity and organization of the central nervous system (CNS) is widely modulated by the presence of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCSFB), which both act as biochemical, dynamic obstacles impeding… read more here.
Keywords: cns diseases; big start; rare cns; cns ... See more keywords
Novel Developments to Enable Treatment of CNS Diseases with Targeted Drug Delivery
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041100
Abstract: The blood-brain barrier (BBB) is a major hurdle for the development of systemically delivered drugs against diseases of the central nervous system (CNS). Because of this barrier there is still a huge unmet need for… read more here.
Keywords: cns diseases; treatment cns; novel; cns ... See more keywords