Cannabinoid Receptors and Ligands: Lessons from CNS Disorders and the Quest for Novel Treatment Venues.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-61663-2_4
Abstract: The potential use of cannabinoids for therapeutic purposes is at the forefront of cannabinoid research which aims to develop innovative strategies to prevent, manage and treat a broad spectrum of human diseases. This chapter briefly reviews… read more here.
Keywords: disorders quest; cannabinoid receptors; receptors ligands; cns disorders ... See more keywords
Fatty acid metabolism in the progression and resolution of CNS disorders.
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DOI: 10.1016/j.addr.2020.01.004
Abstract: Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid metabolism and the fatty acid lipidome in health and disease. A growing body of evidence indicates that imbalances in the metabolism and… read more here.
Keywords: acid metabolism; metabolism; fatty acid; cns disorders ... See more keywords
Extracellular vesicle-associated lipids in central nervous system disorders.
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DOI: 10.1016/j.addr.2020.04.011
Abstract: Increasing evidence indicates that lipid metabolism is disturbed in central nervous system (CNS) disorders, such as multiple sclerosis, Alzheimer's, and Parkinson's disease. Extracellular vesicles (EVs), including exosomes and microvesicles, are nanosized particles that play an… read more here.
Keywords: nervous system; central nervous; disease; associated lipids ... See more keywords
Neurobiological insights and novel therapeutic opportunities for CNS disorders from mGlu receptor allosteric and biased modulation
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2016.10.007
Abstract: HIGHLIGHTSSelective ligands have helped define the neurobiological roles of mGlu receptors.Biased agonism/modulation is a key feature of mGlu signaling.Biased signaling should inform future mGlu drug discovery programs. &NA; The metabotropic glutamate (mGlu) receptor family is… read more here.
Keywords: modulation; neurobiological insights; mglu receptor; cns disorders ... See more keywords
Therapeutic potential of ApoE-mimetic peptides in CNS disorders: Current perspective
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2022.114051
Abstract: The prevalence and burden of CNS disorders are increasing significantly due to the increase in life span and population. The contemporary need in CNS drug discovery is to develop the therapy that can halt the… read more here.
Keywords: therapeutic potential; apoe mimetic; cns disorders; apoe ... See more keywords
Discovery of a Brain Penetrant ATP-competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b01398
Abstract: Recent clinical evaluation of Everolimus for seizure reduction in patients with Tuberous Sclerosis Complex (TSC), a disease with overactivated mTOR signaling, has demonstrated the therapeutic value of mTOR inhibitors for Central Nervous System (CNS) indications.… read more here.
Keywords: brain penetrant; inhibitor; mtor; cns disorders ... See more keywords
Validating indicators of CNS disorders in a swine model of neurological disease
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DOI: 10.1371/journal.pone.0228222
Abstract: Genetically modified swine disease models are becoming increasingly important for studying molecular, physiological and pathological characteristics of human disorders. Given the limited history of these model systems, there remains a great need for proven molecular… read more here.
Keywords: disease; model; indicators cns; cns disorders ... See more keywords
Application of therapeutic nanoplatforms as a potential candidate for the treatment of CNS disorders: Challenges and Possibilities.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220729104433
Abstract: Drug delivery to central nervous system (CNS) diseases is one of the most challenging tasks. The innate blood-brain barrier (BBB) and the blood-cerebrospinal fluid (BCSF) barrier create an obstacle for effective systemic drug delivery to… read more here.
Keywords: nanotechnology; cns; drug delivery; cns disorders ... See more keywords
Mitochondrial Extracellular Vesicles in CNS Disorders: New Frontiers in Understanding the Neurological Disorders of the Brain
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.840364
Abstract: Recent findings have highlighted potential diagnostic and prognostic values of extracellular vesicles (EVs) that contain mitochondrial derived components for neurological disorders. Furthermore, functional influences of vesicles carrying mitochondrial components have been reported. In particular, this… read more here.
Keywords: disorders new; vesicles cns; extracellular vesicles; neurological disorders ... See more keywords
Microglia activation in central nervous system disorders: A review of recent mechanistic investigations and development efforts
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2023.1103416
Abstract: Microglia are the principal resident immune cells in the central nervous system (CNS) and play important roles in the development of CNS disorders. In recent years, there have been significant developments in our understanding of… read more here.
Keywords: central nervous; development; cns disorders; nervous system ... See more keywords
Corrigendum: Genome Editing for CNS Disorders
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.698879
Abstract: [This corrects the article DOI: 10.3389/fnins.2020.579062.]. read more here.
Keywords: genome editing; editing cns; corrigendum genome; cns disorders ... See more keywords