TLR3 agonism re‐establishes CNS immune competence during α4‐integrin deficiency
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.664
Abstract: Natalizumab blocks α4‐integrin‐mediated leukocyte migration into the central nervous system (CNS). It diminishes disease activity in multiple sclerosis (MS), but carries a high risk of progressive multifocal encephalopathy (PML), an opportunistic infection with JV virus… read more here.
Keywords: tlr3 agonism; cns immune; immune competence; integrin deficiency ... See more keywords
Heterozygous NOTCH1 Variants Cause CNS Immune Activation and Microangiopathy
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DOI: 10.1002/ana.26477
Abstract: NOTCH1 belongs to the NOTCH family of proteins that regulate cell fate and inflammatory responses. Somatic and germline NOTCH1 variants have been implicated in cancer, Adams‐Oliver syndrome, and cardiovascular defects. We describe 7 unrelated patients… read more here.
Keywords: variants cause; cns immune; notch1 variants; heterozygous notch1 ... See more keywords
Central nervous system zoning: How brain barriers establish subdivisions for CNS immune privilege and immune surveillance.
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DOI: 10.1111/joim.13469
Abstract: The central nervous system (CNS) coordinates all our body functions. Neurons in the CNS parenchyma achieve this computational task by high speed communication via electrical and chemical signals and thus rely on a strictly regulated… read more here.
Keywords: system; cns immune; brain barriers; cns parenchyma ... See more keywords
Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease
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DOI: 10.3389/fneur.2021.672455
Abstract: The immune system's role is much more than merely recognizing self vs. non-self and involves maintaining homeostasis and integrity of the organism starting from early development to ensure proper organ function later in life. Unlike… read more here.
Keywords: immune; cross talk; talk cns; cns ... See more keywords