The Role of Astrocytes in CNS Inflammation.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in immunology"
DOI: 10.1016/j.it.2020.07.007
Abstract: Astrocytes are the most abundant cell type in the central nervous system (CNS), performing complex functions in health and disease. It is now clear that multiple astrocyte subsets or activation states (plastic phenotypes driven by… read more here.
Keywords: role astrocytes; cns inflammation; astrocytes cns;
Aberrant oligodendroglial-vascular interactions disrupt the Blood Brain Barrier triggering CNS inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Nature neuroscience"
DOI: 10.1038/s41593-019-0369-4
Abstract: Disruption of the blood–brain barrier (BBB) is critical to initiation and perpetuation of disease in multiple sclerosis (MS). We report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from… read more here.
Keywords: blood brain; cns inflammation; blood; brain barrier ... See more keywords
Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2018.1522467
Abstract: ABSTRACT Microglia are innate immune cells in the central nervous system (CNS), that supplies neurons with key factors for executing autophagosomal/lysosomal functions. Macroautophagy/autophagy is a cellular catabolic process that maintains cell balance in response to… read more here.
Keywords: atg16l1; cns inflammation; mir223; autophagy related ... See more keywords
Mechanisms of antigen-induced reversal of CNS inflammation in experimental demyelinating disease
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.abo2810
Abstract: Autoimmune central nervous system (CNS) demyelinating diseases are a major public health burden and poorly controlled by current immunosuppressants. More precise immunotherapies with higher efficacy and fewer side effects are sought. We investigated the effectiveness… read more here.
Keywords: inflammation; cns inflammation; induced reversal; mechanisms antigen ... See more keywords
Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.154824
Abstract: Multiple sclerosis (MS) is an autoimmune inflammatory disease of the CNS that is characterized by demyelination and axonal degeneration. Although several established treatments reduce relapse burden, effective treatments to halt chronic progression are scarce. Single-cell… read more here.
Keywords: small molecule; inflammation; stage cns; cns inflammation ... See more keywords
Systemic and CNS inflammation crosstalk: implications for Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Current Alzheimer research"
DOI: 10.2174/1567205016666190321154618
Abstract: After years of failed therapeutic attempts targeting beta-amyloid (Aβ) in AD, there is now increasing evidence suggesting that inflammation holds a pivotal role in AD pathogenesis and immune pathways can possibly comprise primary therapeutic targets.… read more here.
Keywords: immune; systemic cns; inflammation; disease ... See more keywords
Screening for Viral Nucleic Acids in the Cerebrospinal Fluid of Dogs With Central Nervous System Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.850510
Abstract: Central nervous system (CNS) inflammation is a common cause of neurological dysfunction in dogs. Most dogs with CNS inflammation are diagnosed with presumptive autoimmune disease. A smaller number are diagnosed with an infectious etiology. Additionally,… read more here.
Keywords: inflammation; cns inflammation; infection; cause ... See more keywords
Mesenchymal stem cell-derived exosomes regulate microglia phenotypes: a promising treatment for acute central nervous system injury
Sign Up to like & getrecommendations! Published in 2023 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.363819
Abstract: Abstract There is growing evidence that long-term central nervous system (CNS) inflammation exacerbates secondary deterioration of brain structures and functions and is one of the major determinants of disease outcome and progression. In acute CNS… read more here.
Keywords: cns inflammation; central nervous; acute cns; injury ... See more keywords