Modeling CNS Myelination Using Micropillar Arrays.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7862-5_13
Abstract: Myelination necessitates axons to initiate concentric membrane wrapping by oligodendroglia in the CNS. Here, we describe an in vitro system that models CNS myelination with a minimally permissive environment, termed Binary Indicant for myelination using… read more here.
Keywords: cns myelination; myelination; myelination using; micropillar arrays ... See more keywords
Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.10.044
Abstract: Nervous system function depends on proper myelination for insulation and critical trophic support for axons. Myelination is tightly regulated spatially and temporally, but how it is controlled molecularly remains largely unknown. Here, we identified key… read more here.
Keywords: cns myelination; myelination; programmed cell; cell death ... See more keywords
EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways
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DOI: 10.1126/sciadv.aaz6477
Abstract: Polycomb repressive EED protein orchestrates WNT, BMP, and senescence pathways to ensure proper CNS myelination and repair. Mutations in the polycomb repressive complex 2 (PRC2) can cause Weaver-like syndrome, wherein a patient cohort exhibits abnormal… read more here.
Keywords: wnt bmp; cns myelination; bmp; bmp senescence ... See more keywords