Immune checkpoint inhibitors and radiosurgery for newly diagnosed melanoma brain metastases
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DOI: 10.1007/s11060-018-2930-5
Abstract: IntroductionBrain metastases are common in metastatic melanoma and radiosurgery is often utilized for local control. Immune checkpoint inhibitors (CPIs) play a central role in contemporary melanoma management; however, there is limited data exploring outcomes and… read more here.
Keywords: melanoma; immune checkpoint; cns progression; newly diagnosed ... See more keywords
Brain Penetration of Lorlatinib: Cumulative Incidences of CNS and Non-CNS Progression with Lorlatinib in Patients with Previously Treated ALK-Positive Non-Small-Cell Lung Cancer
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DOI: 10.1007/s11523-020-00702-4
Abstract: Background Lorlatinib is a potent, third-generation ALK/ROS1 tyrosine kinase inhibitor (TKI) designed to penetrate the blood–brain barrier. Objective We report the cumulative incidence of central nervous system (CNS) and non-CNS progression with lorlatinib in patients… read more here.
Keywords: progression; cns progression; cns non; non cns ... See more keywords