Pembrolizumab for patients with leptomeningeal metastasis from solid tumors: efficacy, safety, and cerebrospinal fluid biomarkers
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DOI: 10.1136/jitc-2021-002473
Abstract: Background The benefit of immune checkpoint inhibitors (ICIs) in patients with leptomeningeal metastases (LMM) is unknown. Methods We undertook a phase II trial of pembrolizumab in patients with LMM from solid tumors. Eligible patients had… read more here.
Keywords: cns response; pembrolizumab patients; solid tumors; patients leptomeningeal ... See more keywords
Outcomes of bispecific T-cell engagers in MM patients with central nervous system (CNS) involvement
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DOI: 10.1182/blood-2025-824
Abstract: Background Patients (pts) with multiple myeloma and CNS involvement (CNS MM) have poor outcomes, and we recently showed that CAR-T has activity and is reasonable in this population (Gaballa et al., 2025). We sought to… read more here.
Keywords: cns involvement; cns response; response; cns ... See more keywords