The landscape of neuro-oncology in East Africa: a review of published records
Sign Up to like & getrecommendations! Published in 2021 at "Child's Nervous System"
DOI: 10.1007/s00381-021-05344-z
Abstract: Primary central nervous system (CNS) tumors represent an important and growing cause of worldwide morbidity and mortality. There are global variations in the reported case burden of CNS tumors, with high-income countries reporting a higher… read more here.
Keywords: cns tumors; neuro oncology; care; east africa ... See more keywords
A phase I study of irinotecan and temozolomide with bevacizumab in children with recurrent/refractory central nervous system tumors
Sign Up to like & getrecommendations! Published in 2022 at "Child's Nervous System"
DOI: 10.1007/s00381-022-05479-7
Abstract: Children with relapsed/refractory central nervous system (CNS) tumors require novel combinations of therapies. Irinotecan and temozolomide (IT) is a frequently used therapy with an established toxicity profile. Bevacizumab is an anti-VEGF monoclonal antibody with demonstrated… read more here.
Keywords: cns tumors; refractory central; central nervous; bevacizumab ... See more keywords
Review of the genomic landscape of common pediatric CNS tumors and how data sharing will continue to shape this landscape in the future.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06811-1
Abstract: Over the past decade we have witnessed a rapid increase in our understanding of the molecular characteristics of pediatric central nervous system (CNS) tumors. Studies that utilize genomic sequencing have revealed a heterogeneous group of… read more here.
Keywords: data sharing; cns; landscape; cns tumors ... See more keywords
Outcome of children and adolescents with central nervous system tumors in phase I trials
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2698-z
Abstract: Central nervous system (CNS) tumors are a leading cause of death in pediatric oncology. New drugs are desperately needed to improve survival. We evaluated the outcome of children and adolescents with CNS tumors participating in… read more here.
Keywords: nervous system; central nervous; cns tumors; phase trials ... See more keywords
DICER1 mutations in primary central nervous system tumors: new insights into histologies, mutations, and prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-022-03994-w
Abstract: We sought to characterize clinical outcomes for adult and pediatric patients with primary CNS tumors harboring DICER1 mutations or loss of DICER1. We conducted a retrospective cohort study of 98 patients who were treated between… read more here.
Keywords: cns tumors; glioma; dicer1 mutations; grade glioma ... See more keywords
Does Proton Therapy Have a Future in CNS Tumors?
Sign Up to like & getrecommendations! Published in 2017 at "Current Treatment Options in Neurology"
DOI: 10.1007/s11940-017-0447-4
Abstract: Opinion statementProton therapy is characterized by certain physical properties leading to a reduction in integral dose. As proton therapy becomes more widely available, the ongoing discussion on the real indications for proton therapy becomes more… read more here.
Keywords: therapy; proton therapy; dose escalation; cns tumors ... See more keywords
Imaging Advances for Central Nervous System Tumors.
Sign Up to like & getrecommendations! Published in 2021 at "Hematology/oncology clinics of North America"
DOI: 10.1016/j.hoc.2021.08.002
Abstract: This article reviews recent advances in the use of standard and advanced imaging techniques for diagnosis and treatment of central nervous system (CNS) tumors, including glioma and brain metastasis. Following the recent transition from a… read more here.
Keywords: nervous system; central nervous; cns tumors; imaging advances ... See more keywords
Molecular Diagnostics in Pediatric Brain Tumors: Impact on Diagnosis and Clinical Decision-Making - A Selected Case Series.
Sign Up to like & getrecommendations! Published in 2018 at "Klinische Padiatrie"
DOI: 10.1055/a-0637-9653
Abstract: Central nervous system (CNS) tumors account for the highest mortality among pediatric malignancies. Accurate diagnosis is essential for optimal clinical management. The increasing use of molecular diagnostics has opened up novel possibilities for more precise… read more here.
Keywords: diagnosis; cns tumors; decision making; clinical decision ... See more keywords
The Expressional Pattern of Invasion-Related Extracellular Matrix Molecules in CNS Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Investigation"
DOI: 10.1080/07357907.2018.1545855
Abstract: abstract Aim of the study: Astrocytomas are primary CNS malignancies which infiltrate the peritumoral tissue, even when they are low-grade. Schwannomas are also primary CNS tumors, however, they do not show peritumoral infiltration similarly to… read more here.
Keywords: extracellular matrix; expressional pattern; pattern invasion; cns tumors ... See more keywords
EPCT-08. ACTIVITY OF LAROTRECTINIB IN PEDIATRIC TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION CANCER PATIENTS WITH PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.132
Abstract: Abstract BACKGROUND TRK fusions are oncogenic drivers in a variety of tumors, many involving the CNS. Larotrectinib, a selective FDA- and EMA-approved TRK inhibitor, demonstrated a 79% objective response rate (ORR) and a 35.2-month median… read more here.
Keywords: cns tumors; patients primary; fusion; trk fusion ... See more keywords
EPID-07. A GLOBAL PERSPECTIVE ON THE BURDEN OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.193
Abstract: Abstract Although approximately 90% of pediatric cancer cases exist in low- and middle-income countries, the magnitude of the global burden of pediatric central nervous system (CNS) tumors remains poorly quantified. METHODS: Data from International Incidence… read more here.
Keywords: incidence; pediatric central; central nervous; burden pediatric ... See more keywords