Crystal structure of the rice acyl‐CoA‐binding protein OsACBP2 in complex with C18:3‐CoA reveals a novel pattern of binding to acyl‐CoA esters
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13923
Abstract: Acyl‐CoA‐binding proteins (ACBPs) are a family of proteins that bind acyl‐CoA esters at a conserved acyl‐CoA‐binding domain. ACBPs maintain intracellular acyl‐CoA pools to regulate lipid metabolism. Here, we report on the structure of rice OsACBP2… read more here.
Keywords: osacbp2; c18 coa; acyl coa; coa ... See more keywords
A broader active site in Pyrococcus horikoshii CoA disulfide reductase accommodates larger substrates and reveals evidence of subunit asymmetry
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DOI: 10.1002/2211-5463.12439
Abstract: Within the family of pyridine nucleotide disulfide oxidoreductase (PNDOR), enzymes are a group of single‐cysteine containing FAD‐dependent reductases that utilize a tightly bound coenzyme A to assist in the NAD(P)H‐dependent reduction of di‐, per‐, and… read more here.
Keywords: pyrococcus horikoshii; coa disulfide; disulfide reductase; coa ... See more keywords
A synthetic enzymatic pathway for extremely thermophilic acetone production based on the unexpectedly thermostable acetoacetate decarboxylase from Clostridium acetobutylicum
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26829
Abstract: One potential advantage of an extremely thermophilic metabolic engineering host (T opt ≥ 70°C) is facilitated recovery of volatile chemicals from the vapor phase of an active fermenting culture. This process would reduce purification costs and… read more here.
Keywords: clostridium acetobutylicum; production; extremely thermophilic; acetone production ... See more keywords
Investigating Peptide‐Coenzyme A Conjugates as Chemical Probes for Proteomic Profiling of N‐Terminal and Lysine Acetyltransferases
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DOI: 10.1002/cbic.202200255
Abstract: Acetyl groups are transferred from acetyl‐coenzyme A (Ac‐CoA) to protein N‐termini and lysine side chains by N‐terminal acetyltransferases (NATs) and lysine acetyltransferases (KATs), respectively. Building on lysine‐CoA conjugates as KAT probes, we have synthesized peptide… read more here.
Keywords: investigating peptide; peptide coenzyme; lysine acetyltransferases; coa ... See more keywords
Rapid Biocatalytic Synthesis of Aromatic Acid CoA Thioesters by Using Microbial Aromatic Acid CoA Ligases
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DOI: 10.1002/cbic.202300001
Abstract: Chemically labile ester linkages can be introduced into lignin by incorporation of monolignol conjugates, which are synthesized in planta by acyltransferases that use a coenzyme A (CoA) thioester donor and a nucleophilic monolignol alcohol acceptor. The… read more here.
Keywords: coa ligases; microbial aromatic; acid coa; coa ... See more keywords
ATP Regeneration System in Chemoenzymatic Amide Bond Formation with Thermophilic CoA Ligase
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DOI: 10.1002/cctc.201901870
Abstract: CoA ligases are enzymes catalyzing the ATP‐dependent addition of coenzyme A to carboxylic acids in two steps through an adenylate intermediate. This intermediate can be diverted by a nucleophilic non enzymatic addition of amine to… read more here.
Keywords: system; thermophilic coa; atp regeneration; regeneration system ... See more keywords
Comments on “Inhibition of the ketolytic acetyl CoA supply to tumors could be their ‘Achilles heel’”
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.33017
Abstract: Dear editor, In an interesting letter published recently in this journal, Drs Israël and Schwartz hypothesize that the breakdown of ketone bodies is a tumor cell's “unique source of mitochondrial acetyl CoA”. They propose to… read more here.
Keywords: tumor; coa; acetyl coa; cell ... See more keywords
Involvement of nutrients and nutritional mediators in mitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA synthase gene expression
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DOI: 10.1002/jcp.26177
Abstract: Mitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA (HMG‐CoA) synthase (HMGCS2) catalyses the first step of ketogenesis and is critical in various metabolic conditions. Several nutrient molecules were able to differentially modulate HMGCS2 expression levels. Docosahexaenoic acid (DHA, C22:6, n‐3), eicosapentaenoic… read more here.
Keywords: mitochondrial hydroxy; hydroxy methylglutaryl; expression; coa ... See more keywords
Characterization of exonic variants of uncertain significance in very long‐chain acyl‐CoA dehydrogenase identified through newborn screening
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12492
Abstract: Very long‐chain acyl‐CoA dehydrogenase deficiency (VLCADD) is an autosomal recessive disease resulting from mutations in the ACADVL gene and is among the disorders tested for in newborn screening (NBS). Confirmatory sequencing following suspected VLCADD NBS… read more here.
Keywords: acadvl; vlcad; enzyme activity; activity ... See more keywords
Abnormal concentrations of acetylated amino acids in cerebrospinal fluid in acetyl‐CoA transporter deficiency
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DOI: 10.1002/jimd.12549
Abstract: Acetyl‐CoA transporter 1 (AT‐1) is a transmembrane protein which regulates influx of acetyl‐CoA from the cytosol to the lumen of the endoplasmic reticulum and is therefore important for the posttranslational modification of numerous proteins. Pathological… read more here.
Keywords: acetylated amino; amino acids; acetyl coa; coa transporter ... See more keywords
Relief of CoA sequestration and restoration of mitochondrial function in a mouse model of propionic acidemia
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DOI: 10.1002/jimd.12570
Abstract: Propionic acidemia (PA, OMIM 606054) is a devastating inborn error of metabolism arising from mutations that reduce the activity of the mitochondrial enzyme propionyl‐CoA carboxylase (PCC). The defects in PCC reduce the concentrations of nonesterified… read more here.
Keywords: mitochondrial function; bbp 671; coa; mouse model ... See more keywords