Crystal structure of the rice acyl‐CoA‐binding protein OsACBP2 in complex with C18:3‐CoA reveals a novel pattern of binding to acyl‐CoA esters
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Letters"
DOI: 10.1002/1873-3468.13923
Abstract: Acyl‐CoA‐binding proteins (ACBPs) are a family of proteins that bind acyl‐CoA esters at a conserved acyl‐CoA‐binding domain. ACBPs maintain intracellular acyl‐CoA pools to regulate lipid metabolism. Here, we report on the structure of rice OsACBP2… read more here.
Keywords: osacbp2; c18 coa; acyl coa; coa ... See more keywords
The acyl‐CoA‐binding protein Acb1 regulates mitochondria, lipid droplets, and cell proliferation
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14415
Abstract: Mitochondria are involved in many cellular activities, including energy metabolism and biosynthesis of nucleotides, fatty acids and amino acids. Mitochondrial morphology is a key factor in dictating mitochondrial functions. Here, we report that the acyl‐CoA‐binding… read more here.
Keywords: binding protein; coa binding; lipid droplets; acb1 regulates ... See more keywords
Mefloquine binding to human acyl-CoA binding protein leads to redox stress mediated apoptotic death of human neuroblastoma cells.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2020.01.006
Abstract: Malaria is an infectious disease that is caused by different species of Plasmodium. Several antimalarial drugs are used to counter the spread and infectivity of Plasmodium species. However, humans are also vulnerable to many of… read more here.
Keywords: coa binding; stress; death; acyl coa ... See more keywords
Characterization of Lipid Binding Properties of Plasmodium falciparum Acyl-Coenzyme A Binding Proteins and Their Competitive Inhibition by Mefloquine.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00003
Abstract: Malaria remains a worldwide concern in terms of morbidity and mortality. Limited understanding of the Plasmodium proteome makes it challenging to control malaria. Understanding of the expression and functions of different Plasmodium proteins will help… read more here.
Keywords: acyl coa; mefloquine; coa binding; pfacbps ... See more keywords
Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05042-4
Abstract: Tuberculosis (TB) is a global health problem that affects over 10 million people. There is an urgent need to develop novel antimicrobial therapies to combat TB. To achieve this, a thorough understanding of key validated… read more here.
Keywords: inha; binding pocket; tuberculosis; coa binding ... See more keywords
Acyl-CoA-binding protein family members in laticifers are possibly involved in lipid and latex metabolism of Hevea brasiliensis (the Para rubber tree)
Sign Up to like & getrecommendations! Published in 2017 at "BMC Genomics"
DOI: 10.1186/s12864-017-4419-6
Abstract: BackgroundAcyl-CoA-binding proteins (ACBPs) are mainly involved in acyl-CoA ester binding and trafficking in eukaryotic cells, and their various functions have been characterized in model plants, such as Arabidopsis thaliana (A. thaliana), Oryza sativa (rice), and… read more here.
Keywords: family; lipid latex; coa binding; brasiliensis ... See more keywords
Acyl-CoA binding protein (ACBP) is highly expressed in the developing human kidney.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202205_28749
Abstract: OBJECTIVE Acyl-CoA-binding protein (ACBP), also known as diazepam binding inhibitor (DBI), is a small phylogenetically conserved protein. This ancestral peptide is multifunctional, performing intracellular activities as ACBP protein or extracellular roles as DBI. Several studies… read more here.
Keywords: binding protein; protein acbp; coa binding; kidney ... See more keywords
Molecular Characterization of the Acyl-CoA-Binding Protein Genes Reveals Their Significant Roles in Oil Accumulation and Abiotic Stress Response in Cotton
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14040859
Abstract: Members of the acyl-CoA-binding protein (ACBP) gene family play vital roles in diverse processes related to lipid metabolism, growth and development, and environmental response. Plant ACBP genes have been well-studied in a variety of species… read more here.
Keywords: binding protein; coa binding; cotton; acyl coa ... See more keywords