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Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.03.171
Abstract: Stearoyl Co A desaturase (SCD) is a rate-limiting lipogenic enzyme that plays an integral role in catalyzing the synthesis of monounsaturated fatty acids, chiefly oleate and palmitoleate. Both contribute a major part of the biological…
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Keywords:
desaturase;
stearoyl coa;
protein engineering;
scd ... See more keywords
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Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.11.028
Abstract: In Parkinson's disease (PD), α-synuclein (αS) pathologically impacts the brain, a highly lipid-rich organ. We investigated how alterations in αS or lipid/fatty acid homeostasis affect each other. Lipidomic profiling of human αS-expressing yeast revealed increases in…
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Keywords:
lipidomic analysis;
parkinson;
stearoyl coa;
neurotoxicity ... See more keywords
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Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c05147
Abstract: Stearoyl-CoA desaturase 1 (SCD1) is a rate-limiting enzyme that mainly catalyzes the saturated fatty acids (SFAs) into the monounsaturated fatty acids (MUFAs). The expression level of SCD1 is positively correlated with the marbling score. However,…
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Keywords:
ppar receptor;
stearoyl coa;
bovine;
coa desaturase ... See more keywords
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Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2079253
Abstract: ABSTRACT The primary regulatory gene for fatty acid synthesis, stearoyl-CoA desaturase 1 (SCD1), has been linked to the progression of several malignancies. Its role in cervical cancer remains unclear till now. This paper aimed to…
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Keywords:
cervical cancer;
cancer;
progression;
stearoyl coa ... See more keywords
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Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad015
Abstract: Abstract The evolution of phenotypic plasticity plays an essential role in adaptive responses to climate change; however, its regulatory mechanisms in marine organisms which exhibit high phenotypic plasticity still remain poorly understood. The temperature-responsive trait…
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Keywords:
gigas;
plasticity;
stearoyl coa;
coa desaturase ... See more keywords
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Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-4044
Abstract: Cancer cells are demarcated from normal cells by distinct biological hallmarks, including the reprogramming of metabolic processes. One of the key players involved in metabolic reprogramming is stearoyl-CoA desaturase (SCD), which converts saturated fatty acids…
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Keywords:
coa desaturase;
cancer;
stearoyl coa;
solid tumors ... See more keywords
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Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007261
Abstract: Positive strand RNA viruses, such as dengue virus type 2 (DENV2) expand and structurally alter ER membranes to optimize cellular communication pathways that promote viral replicative needs. These complex rearrangements require significant protein scaffolding as…
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Keywords:
dengue virus;
coa desaturase;
fatty acid;
infection ... See more keywords
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Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11101435
Abstract: Stearoyl-CoA desaturase-1 (SCD1 or delta-9 desaturase, D9D) is a key metabolic protein that modulates cellular inflammation and stress, but overactivity of SCD1 is associated with diseases, including cancer and metabolic syndrome. This transmembrane endoplasmic reticulum…
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Keywords:
desaturase scd1;
stearoyl coa;
sequential dynamics;
scd1 ... See more keywords