Acetyl-CoA-Mediated Post-Biosynthetic Modification of Desferrioxamine B Generates N- and N-O-Acetylated Isomers Controlled by a pH Switch.
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DOI: 10.1021/acschembio.1c00879
Abstract: Biosynthesis of the hydroxamic acid siderophore desferrioxamine D1 (DFOD1, 6), which is the N-acetylated analogue of desferrioxamine B (DFOB, 5), has been delineated. Enzyme-independent Ac-CoA-mediated N-acetylation of 5 produced 6, in addition to three constitutional… read more here.
Keywords: modification; post biosynthetic; acetylated isomers; coa mediated ... See more keywords
Acetyl-CoA-mediated autoacetylation of fatty acid synthase as a metabolic switch of de novo lipogenesis in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2212220119
Abstract: Significance Metabolic homeostasis plays a vital role in animal growth. Here, we show that acetylation of fatty acid synthase (FASN) contributes to de novolipogenesis during fly development. Although acetylation of most proteins is catalyzed by… read more here.
Keywords: acetyl coa; acid synthase; coa mediated; coa ... See more keywords