Molecular cloning and characterization of Cinnamoyl‐CoA reductase promoter gene from Asarum sieboldii Miq
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.2330
Abstract: Asarum sieboldii Miq., a perennial herb of the family Aristolochiaceae, is widely used in China to treat cold, fever, aphthous stomatitis, toothache, gingivitis, and rheumatoid arthritis. Methyleugenol is the most representative pharmacological constituent of this… read more here.
Keywords: promoter; coa reductase; asarum sieboldii; cinnamoyl coa ... See more keywords
Site-directed mutation to improve the enzymatic activity of 5-carboxy-2-pentenoyl-CoA reductase for enhancing adipic acid biosynthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2019.02.006
Abstract: Adipate is a linear C6 dicarboxylic acid, and is a crucial commercial material mainly used to produce the polymer nylon-6,6. In this study, the pathway producing adipate via a reverse reaction of degradation pathway of… read more here.
Keywords: tfu; pentenoyl coa; carboxy pentenoyl; coa ... See more keywords
Isolation of HMG-CoA reductase inhibitors from aronia juice
Sign Up to like & getrecommendations! Published in 2020 at "Food bioscience"
DOI: 10.1016/j.fbio.2020.100535
Abstract: Abstract Daily ingestion of aronia juice is known to reduce serum low density lipoprotein cholesterol levels. However, the mechanism is not clear. In this study, the effect of aronia juice on the activity of human… read more here.
Keywords: reductase; hmg coa; juice; coa reductase ... See more keywords
In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide.
Sign Up to like & getrecommendations! Published in 2018 at "Food chemistry"
DOI: 10.1016/j.foodchem.2018.03.132
Abstract: Previous studies have shown that cowpea protein positively interferes with cholesterol metabolism. In this study, we evaluated the ability of the fraction containing peptides of read more here.
Keywords: peptide; reductase; hmg coa; activity ... See more keywords
An NADH preferring acetoacetyl-CoA reductase is engaged in poly-3-hydroxybutyrate accumulation in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2020.10.022
Abstract: Oxygen supply implies higher production cost and reduction of maximum theoretical yields. Thus, generation of fermentation products is more cost-effective. Aiming to find a key piece for the production of (poly)-3-hydroxybutyrate (PHB) as a fermentation… read more here.
Keywords: coli; poly hydroxybutyrate; coa; acetoacetyl coa ... See more keywords
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101919
Abstract: HMG-CoA reductase (HMGCR) is the rate-limiting enzyme in cholesterol biosynthesis and the target for cholesterol-lowering therapy. Acetaldehyde dehydrogenase 2 (ALDH2) is primarily responsible for detoxifying ethanol-derived acetaldehyde and endogenous lipid aldehydes derived from lipid peroxidation.… read more here.
Keywords: acetaldehyde dehydrogenase; hmg coa; cholesterol synthesis; cholesterol ... See more keywords
Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00107
Abstract: It is a great challenge to develop drugs for treatment of metabolic syndrome. With ganomycin I as a leading compound, 14 meroterpene derivatives were synthesized and screened for their α-glucosidase and HMG-CoA reductase inhibitory activities.… read more here.
Keywords: coa reductase; glucosidase hmg; hmg coa;
Model Lipid Raft Membranes for Embedding Integral Membrane Proteins: Reconstitution of HMG-CoA Reductase and Its Inhibition by Statins
Sign Up to like & getrecommendations! Published in 2022 at "Langmuir"
DOI: 10.1021/acs.langmuir.2c02115
Abstract: For the first time, HMG-CoA reductase, the membrane protein responsible for cholesterol synthesis, was incorporated into a lipid membrane consisting of DOPC:Chol:SM at a 1:1:1 molar ratio, which mimics the lipid rafts of cell membranes.… read more here.
Keywords: coa reductase; lipid raft; hmg coa; membrane ... See more keywords
HMG-CoA Reductase Inhibitors as Drug Leads against Naegleria fowleri.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00428
Abstract: Primary amebic meningoencephalitis (PAM), caused by the free-living ameba Naegleria fowleri, has a fatality rate of over 97%. Treatment of PAM relies on amphotericin B in combination with other drugs, but few patients have survived… read more here.
Keywords: hmg coa; fowleri; naegleria fowleri; drug ... See more keywords
Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46696
Abstract: Novel chemotherapeutics agents are needed to kill Mycobacterium tuberculosis, the main causative agent of tuberculosis (TB). The M. tuberculosis 2-trans-enoyl-ACP(CoA) reductase enzyme (MtInhA) is the druggable bona fide target of isoniazid. New chemotypes were previously… read more here.
Keywords: acp coa; thermodynamics; enoyl acp; tuberculosis ... See more keywords
Improvement of clinical outcomes in patients undergoing peritoneal dialysis using hydroxymethylglutaryl-CoA reductase inhibitors: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Chinese Medical Association"
DOI: 10.1097/jcma.0000000000000840
Abstract: Background: It is unclear whether hydroxymethylglutaryl-CoA reductase inhibitor (statin) therapy decreases the risk of mortality and cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD). Methods: We performed a literature search of PubMed, Cochrane Library,… read more here.
Keywords: coa reductase; patients undergoing; statin therapy; hydroxymethylglutaryl coa ... See more keywords