The mechanism of acetyl-CoA synthase through the lens of a nickel model system
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DOI: 10.1038/s41467-025-60163-z
Abstract: Given the urgent need to develop new methods of CO2/CO utilization, understanding the mechanism of acetyl-CoA synthase (ACS)—a primordial nickel-containing enzyme that converts these gases into a source of cellular energy—is crucial; however, conflicting hypotheses… read more here.
Keywords: mechanism acetyl; coa synthase; mechanism; acetyl coa ... See more keywords
Overexpression of HMG-CoA synthase promotes Arabidopsis root growth and adversely affects glucosinolate biosynthesis
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DOI: 10.1093/jxb/erz420
Abstract: Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) retarded root growth in Arabidopsis seedlings by reducing stigmasterol, auxin, and cytokinin levels. Differentially expressed proteins and metabolite changes revealed a relationship between HMGS and glucosinolate biosynthesis. read more here.
Keywords: coa synthase; glucosinolate biosynthesis; root growth;
Clinical, Biochemical, Molecular, and Outcome Features of Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency in 10 Chinese Patients
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DOI: 10.3389/fgene.2021.816779
Abstract: Background: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency (HMGCS2D) is a rare autosomal recessive metabolic disorder caused by mutations of the HMGCS2 gene. To date, no more than 60 patients have been reported throughout the world. Purpose: To… read more here.
Keywords: synthase deficiency; methylglutaryl coa; mitochondrial hydroxy; chinese patients ... See more keywords
CoA synthase plays a critical role in neurodevelopment and neurodegeneration
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2024.1458475
Abstract: Coenzyme A (CoA), which is widely distributed and vital for cellular metabolism, is a critical molecule essential in both synthesizing and breaking down key energy sources in the body. Inborn errors of metabolism in the… read more here.
Keywords: coa; coa synthase; model; neurodegeneration ... See more keywords