Acyl‐CoA synthetase short‐chain family member 2 (ACSS2) is regulated by SREBP‐1 and plays a role in fatty acid synthesis in caprine mammary epithelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25954
Abstract: Sterol regulatory element binding protein 1 (SREBP‐1) is well‐known as the master regulator of lipogenesis in rodents. Acyl‐CoA synthetase short‐chain family member 2 (ACSS2) plays a key role in lipogenesis by synthesizing acetyl‐CoA from acetate… read more here.
Keywords: fatty acid; lipogenesis; acyl coa; acss2 ... See more keywords
Growing evidence for a role for acyl‐CoA synthetase 1 in immunometabolism
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ce0519-154r
Abstract: Discussion on the role of acyl-CoA synthetase 1 in immunometabolism. read more here.
Keywords: synthetase immunometabolism; acyl coa; coa synthetase; role acyl ... See more keywords
Mouse long-chain Acyl-CoA synthetase 1 is active as a monomer.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108773
Abstract: Fatty acids are essential cellular building blocks and a major energy source. Regardless of their metabolic fate, fatty acids first need to be activated by forming a thioester with a coenzyme A group. This reaction… read more here.
Keywords: active monomer; acyl coa; long chain; coa ... See more keywords
The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency.
Sign Up to like & getrecommendations! Published in 2017 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2017.04.009
Abstract: Malonyl-coenzyme A (malonyl-CoA) is a central metabolite in mammalian fatty acid biochemistry generated and utilized in the cytoplasm; however, little is known about noncanonical organelle-specific malonyl-CoA metabolism. Intramitochondrial malonyl-CoA is generated by a malonyl-CoA synthetase, ACSF3,… read more here.
Keywords: acsf3; malonate; malonyl coa; malonyl ... See more keywords
A homologue of yeast acyl-CoA synthetase Faa1 contributes to cytomembrane functionality involved in development and virulence in the insect pathogenic fungus Beauveria bassiana.
Sign Up to like & getrecommendations! Published in 2022 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2022.105419
Abstract: Acyl-CoA synthetase (ACS) functions as a hub linking lipid metabolism with in cellular physiologies by producing active intermediate of catalyzes acyl-CoA. However, the biological roles of ACS are largely unknown in filamentous fungi. In this… read more here.
Keywords: acyl coa; faa1; coa synthetase; coa ... See more keywords
Biosynthesis of Cyclohexanecarboxyl-CoA Highlights a Promiscuous Shikimoyl-CoA Synthetase and a FAD-Dependent Dehydratase
Sign Up to like & getrecommendations! Published in 2020 at "ACS Catalysis"
DOI: 10.1021/acscatal.0c00406
Abstract: The conversion of shikimate to cyclohexanecarboxyl-CoA (CHC-CoA) involves an exquisite orchestra of multiple enzymes to proceed stereospecifically and avoid aromaticity, but little is known regarding the details of this intriguing enzymatic reaction cascade. Through both… read more here.
Keywords: cyclohexanecarboxyl coa; fad dependent; coa; shikimoyl coa ... See more keywords
Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2361
Abstract: Biotin is an essential vitamin in plants and mammals, functioning as the carbon dioxide carrier within central lipid metabolism. Bacterial pimeloyl-CoA synthetase (BioW) acts as a highly specific substrate-selection gate, ensuring the integrity of the… read more here.
Keywords: pimeloyl coa; coa; using pimeloyl; acid ... See more keywords
Coordinated expression of acetyl CoA synthetase and the ace operon enzymes in Escherichia coli in preparation for adaptation to acetate.
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology"
DOI: 10.1099/mic.0.001230
Abstract: Successful adaptation of Escherichia coli to constant environmental challenges demands the operation of a wide range of regulatory control mechanisms, some of which are global, while others are specific. Here, we show that the ability… read more here.
Keywords: coa synthetase; acetyl coa; acetate; expression ... See more keywords
Asymmetric horseshoe-like assembly of peroxisomal yeast oxalyl-CoA synthetase
Sign Up to like & getrecommendations! Published in 2022 at "Biological Chemistry"
DOI: 10.1101/2022.08.30.505785
Abstract: Abstract Oxalyl-CoA synthetase from Saccharomyces cerevisiae is one of the most abundant peroxisomal proteins in yeast and hence has become a model to study peroxisomal translocation. It contains a C-terminal Peroxisome Targeting Signal 1, which… read more here.
Keywords: horseshoe like; oxalyl coa; coa synthetase; yeast oxalyl ... See more keywords
The Role of Acetyl-CoA Synthetase Short Chain Family Member-1 on Adipocyte Thermogenic Capacity
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734213
Abstract: Obesity is characterized by an increase in adipose mass and is the leading risk factor for type 2 diabetes. Recent research suggests that activation of brown or beige fat and white adipose tissue browning represent… read more here.
Keywords: synthetase short; adipose tissue; physiology; coa synthetase ... See more keywords
Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac170
Abstract: Two well-known protein complexes in mammalian cells, mTOR type 1 and type 2 (mTORC1/2) are involved in several cellular processes such as protein synthesis, cell proliferation and commonly dysregulated in cancer. An acyl-CoA synthetase type… read more here.
Keywords: mtorc1; adrenocortical cells; acyl coa; coa synthetase ... See more keywords