Divergent roles of the acetyl-CoA synthetases RkACS1 and RkACS2 in carotenoid and lipid biosynthesis in Rhodosporidium kratochvilovae
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DOI: 10.1007/s00253-025-13534-x
Abstract: Red yeasts demonstrate considerable potential in industrial and biotechnological applications, particularly in the biosynthesis of carotenoids and lipids, which are valuable secondary metabolites with a wide range of applications. In the oleaginous red yeast Rhodosporidium… read more here.
Keywords: rhodosporidium kratochvilovae; coa synthetases; rkacs1 rkacs2; biosynthesis ... See more keywords
Studying the topology of peroxisomal acyl-CoA synthetases using self-assembling split sfGFP
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DOI: 10.1007/s00418-023-02257-7
Abstract: Peroxisomes are membrane-bounded organelles that contain enzymes involved in multiple lipid metabolic pathways. Several of these pathways require (re-)activation of fatty acids to coenzyme A (CoA) esters by acyl-CoA synthetases, which may take place inside… read more here.
Keywords: assembling split; acyl coa; coa synthetases; topology ... See more keywords
Discovery and mechanism of a highly selective, antifungal acetyl-CoA synthetase inhibitor
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DOI: 10.1038/s41467-025-64183-7
Abstract: Acetyl-CoA synthetases (Acs) have emerged as drug targets for the treatment of cancer, metabolic diseases as well as fungal and parasitic infections. Although a variety of small molecule Acs inhibitors have been discovered, the systematic… read more here.
Keywords: acs inhibitors; coa; coa synthetases; mechanism ... See more keywords
Evolutionary diversification of acyl-CoA synthetases underpins hydrophobic barrier formation across diverse tomato tissues and beyond
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DOI: 10.1093/hr/uhaf114
Abstract: Abstract The transition of plants from aquatic to terrestrial environments required effective barriers against water loss and UV damage. The plant cuticle, a hydrophobic barrier covering aerial surfaces, emerged as a critical innovation, yet how… read more here.
Keywords: acyl coa; coa synthetases; hydrophobic barrier; formation across ... See more keywords