Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms
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DOI: 10.1002/advs.202507533
Abstract: Metastasis remains the leading cause of cancer‐related mortality, yet effective interventions against KRASG12C/D driven lung adenocarcinoma metastasis ared limited. In this study, using KRASG12D/–;TP53–/–;COA4–/– transgenic mice, clinical specimens, organoid models, RNA sequencing, xenograft assays, and… read more here.
Keywords: coa4 driven; evolutionarily conserved; kras mutant; metastasis dual ... See more keywords
Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas
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DOI: 10.1038/s41467-019-12244-z
Abstract: Type III CRISPR-Cas multisubunit complexes cleave ssRNA and ssDNA. These activities promote the generation of cyclic oligoadenylate (cOA), which activates associated CRISPR-Cas RNases from the Csm/Csx families, triggering a massive RNA decay to provide immunity… read more here.
Keywords: crispr cas; cas; coa4; iii crispr ... See more keywords
A yeast suppressor screen links Coa4 to the mitochondrial copper delivery pathway for cytochrome c oxidase.
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DOI: 10.1093/genetics/iyac090
Abstract: Cytochrome c oxidase (CcO) is a multimeric copper-containing enzyme of the mitochondrial respiratory chain that powers cellular energy production. The two core subunits of CcO, Cox1 and Cox2, harbor the catalytic CuB and CuA sites,… read more here.
Keywords: delivery pathway; copper; cytochrome oxidase; copper delivery ... See more keywords