Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms
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DOI: 10.1002/advs.202507533
Abstract: Metastasis remains the leading cause of cancer‐related mortality, yet effective interventions against KRASG12C/D driven lung adenocarcinoma metastasis ared limited. In this study, using KRASG12D/–;TP53–/–;COA4–/– transgenic mice, clinical specimens, organoid models, RNA sequencing, xenograft assays, and… read more here.
Keywords: coa4 driven; evolutionarily conserved; kras mutant; metastasis dual ... See more keywords