Selective Accumulation to Tumor Cells with Coacervate Droplets Formed from a Water-Insoluble Acrylate Polymer.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01343
Abstract: Selective targeting of specific cells without the use of biological ligands has not been achieved. In the present study, we revealed that the coacervate droplets formed from poly(2-methoxyethyl acrylate) (PMEA) and its derivatives selectively accumulated… read more here.
Keywords: pmea derivatives; water; tumor cells; droplets formed ... See more keywords
Encoding Coacervate Droplets with Paramagnetism for Dynamical Reconfigurability and Spatial Addressability.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c09617
Abstract: It is an ongoing endeavor in chemistry and materials science to regulate coacervate droplets on a physiologically relevant spatiotemporal scale to ultimately match or even surpass living cells' precision, complexity, and functionality. Herein, we develop… read more here.
Keywords: encoding coacervate; dynamical reconfigurability; droplets paramagnetism; paramagnetism dynamical ... See more keywords
Active coacervate droplets are protocells that grow and resist Ostwald ripening
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24111-x
Abstract: Active coacervate droplets are liquid condensates coupled to a chemical reaction that turns over their components, keeping the droplets out of equilibrium. This turnover can be used to drive active processes such as growth, and… read more here.
Keywords: active coacervate; ostwald ripening; droplets protocells; coacervate droplets ... See more keywords
DNA dynamics in complex coacervate droplets and micelles
Sign Up to like & getrecommendations! Published in 2022 at "Soft Matter"
DOI: 10.1039/d1sm01787j
Abstract: Single stranded DNA (ssDNA), or another polyanion, can be mixed with polycations to form liquid-like complex coacervates. When the polycations are replaced by cationic–neutral diblock copolymers, complex coacervate core micelles (C3Ms) can be formed instead.… read more here.
Keywords: dna; coacervate droplets; length; droplets micelles ... See more keywords
Assembly of biomimetic microreactors using caged-coacervate droplets.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d2nr05101j
Abstract: Complex coacervates are liquid-like droplets that can be used to create adaptive cell-like compartments. These compartments offer a versatile platform for the construction of bioreactors inspired by living cells. However, the lack of a membrane… read more here.
Keywords: microreactors using; caged coacervate; assembly biomimetic; using caged ... See more keywords
Manipulation of coacervate droplets with an electric field
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203483119
Abstract: Significance Many of the unique properties of biological materials are derived from the highly charged nature of the constituent molecules and their diffuse counterion clouds, which often render such materials intrinsically polarizable, and thus highly… read more here.
Keywords: electric field; manipulation coacervate; coacervate droplets; field ... See more keywords