Structure-Based Stepwise Screening of PPARγ Antagonists as Potential Competitors with NCOA1 Coactivator Peptide for PPARγ CIS Site
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9782-x
Abstract: The small-molecule modulators (agonists and antagonists) of peroxisome proliferator-activated receptor-γ (PPARγ) have been widely used to treat metabolic, cardiovascular and inflammatory diseases such as Type-2 diabetes and heart failure. Existing PPARγ modulators are all developed… read more here.
Keywords: ppar; cis; ppar cis; cis site ... See more keywords
Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2018.12.012
Abstract: Summary The second messenger 3′,5′-cyclic adenosine monophosphate (cAMP) stimulates gene expression via the cAMP-regulated transcriptional coactivator (CRTC) family of cAMP response element-binding protein coactivators. In the basal state, CRTCs are phosphorylated by salt-inducible kinases (SIKs)… read more here.
Keywords: crtc3 pp2a; camp; coactivator; signals stimulate ... See more keywords
The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00593-6
Abstract: Bilateral symmetry is a striking feature of the vertebrate body plan organization. Vertebral precursors, called somites, provide one of the best illustrations of embryonic symmetry. Maintenance of somitogenesis symmetry requires retinoic acid (RA) and its… read more here.
Keywords: embryonic symmetry; coactivator; symmetry; retinoic acid ... See more keywords
Structure of transcription coactivator SAGA
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-1933-5
Abstract: Gene transcription by RNA polymerase II is regulated by activator proteins that recruit the coactivator complexes SAGA (Spt–Ada–Gcn5–acetyltransferase) 1 , 2 and transcription factor IID (TFIID) 2 – 4 . SAGA is required for all… read more here.
Keywords: transcription; saga; module; core module ... See more keywords
Overlapping coactivator function is required for transcriptional activation by the Candida glabrata Pdr1 transcription factor
Sign Up to like & getrecommendations! Published in 2024 at "Genetics"
DOI: 10.1093/genetics/iyae115
Abstract: Abstract Azole resistance in the pathogenic yeast Candida glabrata is a serious clinical complication and increasing in frequency. The majority of resistant organisms have been found to contain a substitution mutation in the Zn2Cys6 zinc… read more here.
Keywords: transcription factor; coactivator; candida glabrata; pdr1 ... See more keywords
Steroid receptor coactivator 1 promotes human hepatocellular carcinoma invasiveness through enhancing MMP‐9
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.18171
Abstract: SRC‐1 functions as a transcriptional coactivator for steroid receptors and various transcriptional factors. Notably, SRC‐1 has been implicated in oncogenic roles in multiple cancers, including breast cancer and prostate cancer. Previous investigations from our laboratory… read more here.
Keywords: expression; coactivator; mmp expression; hcc metastasis ... See more keywords
Coactivator starts and stalls
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.358.6366.1016-d
Abstract: Transcription In embryonic development and growth control, the histone acetyltransferase p300/CBP (CBP) serves as a transcriptional coactivator with hundreds of different partner transcription factors. By examining the role of CBP in fruitfly cells, Boija et… read more here.
Keywords: starts stalls; coactivator starts; cbp; coactivator ... See more keywords
CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-1049
Abstract: This study identifies CHD4 as a HIF coactivator and elucidates the fundamental mechanism underlying CHD4-mediated HIF transactivation in breast tumors. Recruitment of RNA polymerase II to hypoxia-inducible factor (HIF) target genes under normoxia is a… read more here.
Keywords: hypoxia; cancer; breast cancer; coactivator ... See more keywords
Abstract 1404: Coactivator-associated arginine methyltransferase 1 regulates the transcriptional coactivator function of glioblastoma tumor suppressor Quaking
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1404
Abstract: As the most common and malignant primary brain tumor in adults, glioblastoma (GBM) remains highly refractory to current therapeutic efforts, and patient outcome has not markedly improved in the past decades. Significant intratumor heterogeneity drives… read more here.
Keywords: transcriptional coactivator; coactivator; tumor suppressor; gbm ... See more keywords
Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states
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DOI: 10.1371/journal.pcbi.1009977
Abstract: The coactivator KIX of CBP uses two binding surfaces to recognize multiple activators and exhibits allostery in ternary complex formation. Activator•coactivator interactions are central to transcriptional regulation, yet the microscopic origins of allostery in dynamic… read more here.
Keywords: allostery dynamic; molecular recognition; coactivator; micro states ... See more keywords
Regulation of Hepatic Gluconeogenesis by Nuclear Receptor Coactivator 6
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.2222
Abstract: Nuclear receptor coactivator 6 (NCOA6) is a transcriptional coactivator of nuclear receptors and other transcription factors. A general Ncoa6 knockout mouse was previously shown to be embryonic lethal, but we here generated liver-specific Ncoa6 knockout… read more here.
Keywords: nuclear receptor; coactivator; lko mice; receptor coactivator ... See more keywords