Structure-Based Stepwise Screening of PPARγ Antagonists as Potential Competitors with NCOA1 Coactivator Peptide for PPARγ CIS Site
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9782-x
Abstract: The small-molecule modulators (agonists and antagonists) of peroxisome proliferator-activated receptor-γ (PPARγ) have been widely used to treat metabolic, cardiovascular and inflammatory diseases such as Type-2 diabetes and heart failure. Existing PPARγ modulators are all developed… read more here.
Keywords: ppar; cis; ppar cis; cis site ... See more keywords
Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment
Sign Up to like & getrecommendations! Published in 2019 at "iScience"
DOI: 10.1016/j.isci.2018.12.012
Abstract: Summary The second messenger 3′,5′-cyclic adenosine monophosphate (cAMP) stimulates gene expression via the cAMP-regulated transcriptional coactivator (CRTC) family of cAMP response element-binding protein coactivators. In the basal state, CRTCs are phosphorylated by salt-inducible kinases (SIKs)… read more here.
Keywords: crtc3 pp2a; camp; coactivator; signals stimulate ... See more keywords
The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00593-6
Abstract: Bilateral symmetry is a striking feature of the vertebrate body plan organization. Vertebral precursors, called somites, provide one of the best illustrations of embryonic symmetry. Maintenance of somitogenesis symmetry requires retinoic acid (RA) and its… read more here.
Keywords: embryonic symmetry; coactivator; symmetry; retinoic acid ... See more keywords
Structure of transcription coactivator SAGA
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-1933-5
Abstract: Gene transcription by RNA polymerase II is regulated by activator proteins that recruit the coactivator complexes SAGA (Spt–Ada–Gcn5–acetyltransferase) 1 , 2 and transcription factor IID (TFIID) 2 – 4 . SAGA is required for all… read more here.
Keywords: transcription; saga; module; core module ... See more keywords
Coactivator starts and stalls
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.358.6366.1016-d
Abstract: Transcription In embryonic development and growth control, the histone acetyltransferase p300/CBP (CBP) serves as a transcriptional coactivator with hundreds of different partner transcription factors. By examining the role of CBP in fruitfly cells, Boija et… read more here.
Keywords: starts stalls; coactivator starts; cbp; coactivator ... See more keywords
CHD4 Promotes Breast Cancer Progression as a Coactivator of Hypoxia-Inducible Factors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-20-1049
Abstract: This study identifies CHD4 as a HIF coactivator and elucidates the fundamental mechanism underlying CHD4-mediated HIF transactivation in breast tumors. Recruitment of RNA polymerase II to hypoxia-inducible factor (HIF) target genes under normoxia is a… read more here.
Keywords: hypoxia; cancer; breast cancer; coactivator ... See more keywords
Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009977
Abstract: The coactivator KIX of CBP uses two binding surfaces to recognize multiple activators and exhibits allostery in ternary complex formation. Activator•coactivator interactions are central to transcriptional regulation, yet the microscopic origins of allostery in dynamic… read more here.
Keywords: allostery dynamic; molecular recognition; coactivator; micro states ... See more keywords
Regulation of Hepatic Gluconeogenesis by Nuclear Receptor Coactivator 6
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.2222
Abstract: Nuclear receptor coactivator 6 (NCOA6) is a transcriptional coactivator of nuclear receptors and other transcription factors. A general Ncoa6 knockout mouse was previously shown to be embryonic lethal, but we here generated liver-specific Ncoa6 knockout… read more here.
Keywords: nuclear receptor; coactivator; lko mice; receptor coactivator ... See more keywords
Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Endocrine-related cancer"
DOI: 10.1530/erc-19-0482
Abstract: Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy without effective therapeutic options to improve survival. Steroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator whose amplification and/or overexpression has been identified in many cancers. In this… read more here.
Keywords: cancer; steroid receptor; receptor coactivator; coactivator ... See more keywords
Characterization of a Sea Urchin IQ Motif Containing Protein D as a Coactivator of Nuclear Receptors
Sign Up to like & getrecommendations! Published in 2017 at "Zoological Science"
DOI: 10.2108/zs160157
Abstract: Nuclear receptor (NR) interacting proteins, such as coactivators and corepressors, play a crucial role in specifying the transcriptional activity of the receptor. However, little is known about the functional features of the NR coregulators in… read more here.
Keywords: protein; motif; coactivator; sea urchin ... See more keywords
Peroxisome Proliferator Activated Receptor Gamma Coactivator-1 Alpha: A Double-Edged Sword in Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009622666220330194149
Abstract: Peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1α/PPARGC1A) is a pivotal transcriptional coactivator involved in the regulation of mitochondrial metabolism, including biogenesis and oxidative metabolism. PGC-1α is finely regulated by AMP-activated protein kinases (AMPKs), the… read more here.
Keywords: peroxisome proliferator; proliferator activated; coactivator; cancer ... See more keywords