Targeting the R domain of coagulase by active vaccination protects mice against lethal Staphylococcus aureus infection.
Sign Up to like & getrecommendations! Published in 2018 at "Microbes and infection"
DOI: 10.1016/j.micinf.2018.11.001
Abstract: Coagulase (Coa) secreted by Staphylococcus aureus is associated with the establishment of staphylococcal disease, which activates host prothrombin and generates fibrin shields. The R domain of Coa, consisting of several conserved repeats, is important in… read more here.
Keywords: aureus infection; staphylococcus aureus; coar6; coagulase ... See more keywords
RGD delivery of truncated coagulase to tumor vasculature affords local thrombotic activity to induce infarction of tumors in mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05326-9
Abstract: Induction of thrombosis in tumor vasculature represents an appealing strategy for combating cancer. Herein, we combined unique intrinsic coagulation properties of staphylocoagulase with new acquired functional potentials introduced by genetic engineering, to generate a novel… read more here.
Keywords: tumor vasculature; thrombotic activity; activity; truncated coagulase ... See more keywords
Distribution of Aminoglycoside-Modifying Enzymes and Molecular Analysis of the Coagulase Gene in Clinical Isolates of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2019 at "Microbial drug resistance"
DOI: 10.1089/mdr.2017.0121
Abstract: Enzymatic alteration of aminoglycosides by aminoglycoside-modifying enzymes (AMEs) is the major mechanism of resistance to aminoglycosides. The purpose of this study was to determine the frequency of AME genes, staphylococcal chromosomal cassette mec (SCCmec) types,… read more here.
Keywords: analysis; aureus; aminoglycoside modifying; resistance ... See more keywords
Closing the Brief Case: Bacteremia and Vertebral Osteomyelitis Due to Staphylococcus schleiferi
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.00512-17
Abstract: Answer: A. The tube coagulase test detects the presence of free coagulase that is secreted by S. aureus and other coagulase-positive Staphylococcus species. The slide coagulase test detects the presence of bound coagulase (also known… read more here.
Keywords: staphylococcus; brief case; case bacteremia; bacteremia vertebral ... See more keywords
Clinical Characteristics of Methicillin-resistant Coagulase-negative Staphylococcal Bacteremia in a Tertiary Hospital
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DOI: 10.2169/internalmedicine.56.7715
Abstract: Objective Coagulase-negative staphylococci are among the most frequently isolated microorganisms in blood cultures. The aim of this study was to assess [1] the clinical characteristics of methicillin-resistant, coagulase-negative staphylococci bacteremia and [2] the susceptibility of… read more here.
Keywords: negative staphylococci; methicillin resistant; resistant coagulase; coagulase negative ... See more keywords
Coagulase-negative staphylococci species affect biofilm formation of other coagulase-negative and coagulase-positive staphylococci.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of dairy science"
DOI: 10.3168/jds.2017-12629
Abstract: Coagulase-negative staphylococci (CNS) are considered to be commensal bacteria in humans and animals, but are now also recognized as etiological agents in several infections, including bovine mastitis. Biofilm formation appears to be an important factor… read more here.
Keywords: biofilm formation; biofilm phenotype; biofilm; coagulase negative ... See more keywords
The SaeRS Two-Component System Controls Survival of Staphylococcus aureus in Human Blood through Regulation of Coagulase
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DOI: 10.3389/fcimb.2017.00204
Abstract: The SaeRS two-component system plays important roles in regulation of key virulence factors and pathogenicity. In this study, however, we found that the deletion mutation of saeRS enhanced bacterial survival in human blood, whereas complementation… read more here.
Keywords: saers two; human blood; blood; coagulase ... See more keywords
Staphylococcus aureus coa gene sequence analysis can prevent misidentification of coagulase-negative strains and contribute to their control in dairy cow herds
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1120305
Abstract: Accurate and precise differentiation of staphylococci isolated from milk is of importance for udder health management. In particular, the rapid and specific identification of Staphylococcus aureus plays an essential role in the prevention and treatment… read more here.
Keywords: coa gene; sequence; staphylococcus aureus; aureus ... See more keywords