Maturation of coagulation factor IX during Xase formation as deduced using factor VIII‐derived peptides
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DOI: 10.1002/2211-5463.12653
Abstract: Blood coagulation involves extrinsic and intrinsic pathways, which merge at the activation step of blood coagulation factor X to factor Xa. This step is catalysed by the extrinsic or intrinsic Xase, which consists of a… read more here.
Keywords: coagulation; xase; fviiia; coagulation factor ... See more keywords
Quantification of Coagulation Factor VIII by Selective Reaction Monitoring.
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DOI: 10.1007/978-1-4939-7312-5_22
Abstract: Coagulation factor VIII (FVIII) is an important glycoprotein involved in the extrinsic coagulation cascade. Mutations in FVIII gene results in hemophilia A, a recessive coagulation disorder that is clinically managed by administration of purified FVIII… read more here.
Keywords: coagulation; reaction monitoring; factor viii; coagulation factor ... See more keywords
Factor Concentrate-Based Approaches to Blood Conservation in Cardiac Surgery: European Perspectives in 2020
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DOI: 10.1007/s40140-020-00382-w
Abstract: Purpose of Review Recent European guidelines and expert consensus statements recommend the use of coagulation factor concentrates to improve hemostasis in bleeding patients after cardiac surgery and for patient blood management. This review summarizes the… read more here.
Keywords: coagulation; coagulation factor; cardiac surgery; factor concentrates ... See more keywords
Distinct 3-disulfide-bonded isomers of tridegin differentially inhibit coagulation factor XIIIa: The influence of structural stability on bioactivity.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112474
Abstract: Tridegin is a 66mer cysteine-rich coagulation factor XIIIa (FXI-IIa) inhibitor from the giant amazon leech Haementeria ghilianii of yet unknown disulfide connectivity. This study covers the structural and functional characterization of five different 3-disulfide-bonded tridegin… read more here.
Keywords: coagulation factor; disulfide bonded; disulfide; factor xiiia ... See more keywords
A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brain
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DOI: 10.1016/j.neuroscience.2019.05.040
Abstract: Coagulation factor XII (FXII) is synthesized in the liver and secreted into the circulation, where it initiates the contact activation system. Although typically thought to be restricted to the circulation, FXII protein has been found… read more here.
Keywords: isoform; factor xii; coagulation factor; fxii ... See more keywords
Coagulation Factor Hyperfunction After Subarachnoid Hemorrhage Induces Deep Venous Thrombosis.
Sign Up to like & getrecommendations! Published in 2018 at "World neurosurgery"
DOI: 10.1016/j.wneu.2017.09.200
Abstract: OBJECTIVE To explore the change of coagulation function and associated potential mechanisms and the relationship between coagulation disorders and deep venous thrombosis (DVT) after subarachnoid hemorrhage (SAH) within 3 days of onset. METHODS A total… read more here.
Keywords: coagulation; venous thrombosis; deep venous; subarachnoid hemorrhage ... See more keywords
Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
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DOI: 10.1038/s41598-021-83731-x
Abstract: Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a… read more here.
Keywords: coagulation; factor vii; viral replication; undetectable viral ... See more keywords
Thrombotic complications in adult patients with severe single coagulation factor or platelet defects – an overview
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DOI: 10.1080/17474086.2019.1570126
Abstract: ABSTRACT Introduction: Even though thrombotic events are rare in patients with coagulation deficiencies, several cases of both arterial and venous thromboses have been reported in patients with single coagulation factor defects and platelet defects. Thromboses… read more here.
Keywords: coagulation factor; coagulation; platelet defects; single coagulation ... See more keywords
Pharmacological management of rare coagulation factor deficiencies besides hemophilia
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DOI: 10.1080/17474086.2020.1796622
Abstract: ABSTRACT Introduction Rare coagulation factor deficiencies are less-known disorders with variable effects on the patient’s life. Management of such patients is a challenge due to the paucity of evidence-based data, more so when patients with… read more here.
Keywords: management; rare coagulation; coagulation factor; factor deficiencies ... See more keywords
Coagulation factor dysregulation in polycystic ovary syndrome is an epiphenomenon of obesity
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DOI: 10.1111/cen.14904
Abstract: Obese women with polycystic ovary syndrome (PCOS) exhibit a hypercoagulable state, with the suggestion that this may be obesity‐driven rather than an intrinsic facet of PCOS; however, this has not yet been definitively determined since… read more here.
Keywords: factor dysregulation; polycystic ovary; ovary syndrome; coagulation factor ... See more keywords
Establishment of gene‐edited pigs expressing human blood‐coagulation factor VII and albumin for bioartificial liver use
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.14666
Abstract: Bioartificial livers (BALs) are considered as a solution to bridge patients with acute liver failure to liver transplantation or to assist in spontaneous recovery for patients with end‐stage liver disease. Pig is the best donor… read more here.
Keywords: factor vii; pigs expressing; vii albumin; liver ... See more keywords