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   Articles with "coagulation factor" as a keyword



Maturation of coagulation factor IX during Xase formation as deduced using factor VIII‐derived peptides

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recommendations! Published in 2019 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.12653

Abstract: Blood coagulation involves extrinsic and intrinsic pathways, which merge at the activation step of blood coagulation factor X to factor Xa. This step is catalysed by the extrinsic or intrinsic Xase, which consists of a… read more here.

Keywords: coagulation; xase; fviiia; coagulation factor ... See more keywords

Quantification of Coagulation Factor VIII by Selective Reaction Monitoring.

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recommendations! Published in 2018 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-7312-5_22

Abstract: Coagulation factor VIII (FVIII) is an important glycoprotein involved in the extrinsic coagulation cascade. Mutations in FVIII gene results in hemophilia A, a recessive coagulation disorder that is clinically managed by administration of purified FVIII… read more here.

Keywords: coagulation; reaction monitoring; factor viii; coagulation factor ... See more keywords
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Factor Concentrate-Based Approaches to Blood Conservation in Cardiac Surgery: European Perspectives in 2020

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recommendations! Published in 2020 at "Current Anesthesiology Reports"

DOI: 10.1007/s40140-020-00382-w

Abstract: Purpose of Review Recent European guidelines and expert consensus statements recommend the use of coagulation factor concentrates to improve hemostasis in bleeding patients after cardiac surgery and for patient blood management. This review summarizes the… read more here.

Keywords: coagulation; coagulation factor; cardiac surgery; factor concentrates ... See more keywords

Distinct 3-disulfide-bonded isomers of tridegin differentially inhibit coagulation factor XIIIa: The influence of structural stability on bioactivity.

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recommendations! Published in 2020 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2020.112474

Abstract: Tridegin is a 66mer cysteine-rich coagulation factor XIIIa (FXI-IIa) inhibitor from the giant amazon leech Haementeria ghilianii of yet unknown disulfide connectivity. This study covers the structural and functional characterization of five different 3-disulfide-bonded tridegin… read more here.

Keywords: coagulation factor; disulfide bonded; disulfide; factor xiiia ... See more keywords

A Short Isoform of Coagulation Factor XII mRNA Is Expressed by Neurons in the Human Brain

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recommendations! Published in 2019 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2019.05.040

Abstract: Coagulation factor XII (FXII) is synthesized in the liver and secreted into the circulation, where it initiates the contact activation system. Although typically thought to be restricted to the circulation, FXII protein has been found… read more here.

Keywords: isoform; factor xii; coagulation factor; fxii ... See more keywords

Coagulation Factor Hyperfunction After Subarachnoid Hemorrhage Induces Deep Venous Thrombosis.

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recommendations! Published in 2018 at "World neurosurgery"

DOI: 10.1016/j.wneu.2017.09.200

Abstract: OBJECTIVE To explore the change of coagulation function and associated potential mechanisms and the relationship between coagulation disorders and deep venous thrombosis (DVT) after subarachnoid hemorrhage (SAH) within 3 days of onset. METHODS A total… read more here.

Keywords: coagulation; venous thrombosis; deep venous; subarachnoid hemorrhage ... See more keywords

Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-62789-5

Abstract: Coagulation factor XII has been identified as a potential drug target that could prevent thrombosis without increasing the risk of bleeding. However, human data to support the development of factor XII-directed therapeutics are lacking. To… read more here.

Keywords: factor; factor xii; venous thromboembolism; coagulation factor ... See more keywords
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Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-83731-x

Abstract: Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a… read more here.

Keywords: coagulation; factor vii; viral replication; undetectable viral ... See more keywords

Genetic analysis for an inherited coagulation factor XII deficiency pedigree.

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recommendations! Published in 2025 at "Hematology"

DOI: 10.1080/16078454.2025.2524235

Abstract: ABSTRACT Objective: This study aimed to analyze the phenotype and genotype of a consanguineous marriage pedigree with inherited coagulation factor Ⅻ (FⅫ) deficiency and to elucidate the potential molecular pathogenesis. Clinical presentation: The proband was… read more here.

Keywords: analysis; coagulation; inherited coagulation; deficiency pedigree ... See more keywords

Thrombotic complications in adult patients with severe single coagulation factor or platelet defects – an overview

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recommendations! Published in 2019 at "Expert Review of Hematology"

DOI: 10.1080/17474086.2019.1570126

Abstract: ABSTRACT Introduction: Even though thrombotic events are rare in patients with coagulation deficiencies, several cases of both arterial and venous thromboses have been reported in patients with single coagulation factor defects and platelet defects. Thromboses… read more here.

Keywords: coagulation factor; coagulation; platelet defects; single coagulation ... See more keywords

Pharmacological management of rare coagulation factor deficiencies besides hemophilia

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recommendations! Published in 2020 at "Expert Review of Hematology"

DOI: 10.1080/17474086.2020.1796622

Abstract: ABSTRACT Introduction Rare coagulation factor deficiencies are less-known disorders with variable effects on the patient’s life. Management of such patients is a challenge due to the paucity of evidence-based data, more so when patients with… read more here.

Keywords: management; rare coagulation; coagulation factor; factor deficiencies ... See more keywords